→ apa9394:好文! 05/04 23:10
Monoclonal antibody is the first generation of HIV vaccine, and
it has failed so far, and it is expected to fail in the foreseen
future. The primary challenge of using monoclonal antibody
against HIV is two folds. First antibody can only target
the coating proteins of free virus, which limits the number of
proteins and sites antibody can target. Secondly, the two
env proteins, gp41 and gp120, are highly variable such that
HIV can easily mutate at antibody binding site (epitopes)
and thus escape monoclonal antibody targeting.
These are the two primary reasons why a lot of people have
given up on making a monoclonal antibody based vaccine.
for reference, Jay Berzofsky, AJ McMichael, Bruce Walker, and
Rowland-Jones are good names to look up.
※ 引述《Claude.bbs@bbs.badcow.com.tw (想找個人真心來疼)》之銘言：
: 現在已經有發展單株抗體用來對抗HIV嗎?
: 成效又是如何?
: 遇到的瓶頸又是怎樣?
: 有沒有什麼比較大的缺點
: 懇請大家可以給點答案或資訊
: 謝謝^^~
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