※ 引述《lingon (風往哪裡去)》之銘言：
: Monoclonal antibody is the first generation of HIV vaccine, and
: it has failed so far, and it is expected to fail in the foreseen
: future. The primary challenge of using monoclonal antibody
: against HIV is two folds. First antibody can only target
: the coating proteins of free virus, which limits the number of
: proteins and sites antibody can target. Secondly, the two
: env proteins, gp41 and gp120, are highly variable such that
: HIV can easily mutate at antibody binding site (epitopes)
: and thus escape monoclonal antibody targeting.
: These are the two primary reasons why a lot of people have
: given up on making a monoclonal antibody based vaccine.
: for reference, Jay Berzofsky, AJ McMichael, Bruce Walker, and
: Rowland-Jones are good names to look up.
可以請問一下嗎?我以前有個想法
既然HIV無法治療的主要原因,是因為他突變的太快了
那有沒有可能在治療上
我們先施與能 induce HIV RNA repair protein 的compound
使他在replication時,修補能力增加,減少mutation機會
再配合其它療法予以治療?
謝謝...
: ※ 引述《Claude.bbs@bbs.badcow.com.tw (想找個人真心來疼)》之銘言：
: : 現在已經有發展單株抗體用來對抗HIV嗎?
: : 成效又是如何?
: : 遇到的瓶頸又是怎樣?
: : 有沒有什麼比較大的缺點
: : 懇請大家可以給點答案或資訊
: : 謝謝^^~
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