http://www.libertytimes.com.tw/2008/new/oct/20/today-int7.htm
2008-10-20
《中英對照讀新聞》Scientists uncover new gene link to male pattern
baldness科學家找到與雄性禿有關的新基因
◎ 管淑平
Scientists have discovered a genetic link to baldness that helps
explain why some men may inherit their shiny pates from their fathers.
科學家已經發現禿頭的基因關係，這有助於解釋為何有些男人會從父輩遺傳頂上無
毛。
Tests on more than 1,000 bald men revealed two genes that, active
together, make a man seven times more likely to lose his hair. Around
14% of men are thought to carry both gene variants.
對1000多名禿頭男進行的檢測發現，兩種基因一起作用的話，會讓禿頭的機率增加
6倍。據信有大約14%的男性都帶有這兩種基因突變。
One of the genes identified by the scientists was already known. It
sits on the female X chromosome. The second gene region the study
identified is new and gives researchers their first clue to how
baldness may be passed from father to son. The tests showed certain
gene variations in a chunk of DNA located on chromosome 20 contribute
substantially to male pattern baldness, although it is not clear what
the genes do.
科學家找到的其中一個基因已知與禿頭有關，是位於女性X染色體上。第二個基因
是新發現的，讓研究人員首次有線索能了解禿頭何以可能由父親遺傳給兒子。檢測
顯示，第20號染色體上一段DNA的特定基因變異明顯會造成禿頭，但是並不清楚箇
中原因。
The findings give scientists a much clearer picture of the genetic
causes of male pattern baldness. "The one in seven men who carry both
these risk factors are almost certain to go bald before the age of 50,"
said The report published in the Nature Genetics journal.
這項發現讓科學家更清楚了解雄性禿的基因成因。這份在「自然基因」期刊發表的
報告說：「同時帶有這兩種基因的男性，每7人就有1人幾乎可以肯定50歲前會禿頭
。」
新聞辭典
male pattern baldness：名詞，雄性禿。
pate：名詞，頭、頭頂。例句：Male pattern baldness is like a nightmare
for men, but men with a bald pate are always reluctant to seek medical
help. （雄性禿對男人來說有如惡夢，但是頂上無毛的男人往往對尋求醫療協助猶
豫不決。）
pass from A to B：動詞片語，傳承、遺傳。例句：Some disease can be pass
from parents to their children. （有的疾病會從父母遺傳給小孩。）
期刊連結:
http://www.nature.com/ng/journal/vaop/ncurrent/abs/ng.255.html
Brief Communication abstract
Nature Genetics
Published online: 12 October 2008 | doi:10.1038/ng.255
Male-pattern baldness susceptibility locus at 20p11
J Brent Richards1,2, Xin Yuan3, Frank Geller4, Dawn Waterworth3,
Veronique Bataille1, Daniel Glass1, Kijoung Song3, Gerard Waeber5,
Peter Vollenweider5, Katja K H Aben6,7, Lambertus A Kiemeney8,9, Bragi
Walters4, Nicole Soranzo1,10, Unnur Thorsteinsdottir4, Augustine Kong4,
Thorunn Rafnar4, Panos Deloukas10, Patrick Sulem4, Hreinn Stefansson4,
Kari Stefansson4, Tim D Spector1,11 & Vincent Mooser3,11
We conducted a genome-wide association study for androgenic alopecia in
1,125 men and identified a newly associated locus at chromosome
20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60,
P = 1.1 times 10-14 for rs1160312). The one man in seven who harbors
risk alleles at both 20p11.22 and AR (encoding the androgen receptor)
has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P =
3.7 times 10-15).
Top of page
1. Department of Twin Research and Genetic Epidemiology, King's
College London, London SE1 7EH, UK.
2. Department of Medicine, Jewish General Hospital, Faculty of
Medicine, McGill University, Montréal, Québec H3T 1E2, Canada.
3. Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania
19406, USA.
4. deCODE Genetics, Reykjavik 101, Iceland.
5. Department of Internal Medicine, CHUV University Hospital,
Lausanne 1011, Switzerland.
6. Comprehensive Cancer Center IKO, Radboud University Nijmegen
Medical Center, Nijmegen 6501 BG, The Netherlands.
7. Department of Epidemiology and Biostatistics, Radboud University
Nijmegen Medical Center, Nijmegen 6500 HB, The Netherlands.
8. Department of Epidemiology and Biostatistics, Radboud University
Nijmegen Medical Center, Nijmegen 6500 HB, The Netherlands.
9. Department of Urology, Radboud University Nijmegen Medical
Center, Nijmegen 6525 GA, The Netherlands.
10. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus,
Hinxton CB10 1SA, UK.
11. These authors contributed equally to this work.
Correspondence to: Tim D Spector1,11 e-mail: tim.spector@kcl.ac.uk
心得: 科科, 葛蘭素要發了
--
※ 發信站: 批踢踢實業坊(ptt.cc)
◆ From: 76.25.201.178
※ leoblack:轉錄至看板 hair_loss 10/21 00:54