推 wenhaoshen:為什麼？ 09/22 22:07
推 kaifish:TSG應該不是以是否影響cell growth而進行定義 09/23 16:33
推 wenhaoshen:是喔...那定義是？ 09/23 20:15
→ soom:樓上版友何不提出您認為的定義？這樣也比較好討論 09/23 22:09
The biology of Cancer; Robert A.Weinberg
Ch7 TSG-synopsis
p247
In the great majority of cases, both copies of a TSG must be inactivated
before an incipient cancer cell enjoys any proliferative or survival
advantages. Still, this rule is not a hard-and-fast obe. In some instances,
such as the case of Nf1 gene, it appears that loss of one copy of a TSG
already provides a measure of growth advantage of a cell. Mutant alleles of
another TSG-p53 can create a partially mutant cell phenotype by actively
interfering with the going functions of coexisting wilde-type allele.
---
p248
The functional test has been made more rigorous by determining whether a
candidate TSG, when expressed at normal, physiologic levels, halts the growth
of a cancer cell lacking expression of this gene while leaving normal, wild-
type cells from the same tissue unaffected.
---
These consideration have led to an even stricker genetic definition of a TSG:
a gene can be called a tumor supressor gene only if it undergoes LOH in
many tumor cell genomes and if the resulting homozygous alleles bear clear
and obvious inactivating mutations.
---
對了 假如你knockdown的是wt-p53..剩下30%的wt-p53還是足夠執行功能XD
--
※ 發信站: 批踢踢實業坊(ptt.cc)
◆ From: 163.15.174.69
推 wenhaoshen:Thank you for your reply. 09/24 11:04