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http://ntu-bst.blogspot.tw/2013/09/101-pm-1320-1520-201.html
時間: 2013/ 10/ 01 (週二）下午 13:20-15:20
地點: 臺灣大學 共同教學館 201 教室
演講人: 周 芷 院士 (不連續基因發現者。美國國家科學院院士。阿拉巴馬
大學分子遺傳學教授。大學聯考三類組榜首。臺大生化科技學系系友）
報名網址: http://goo.gl/MkQrQy
周芷教授維基百科介紹: http://tinyurl.com/LC20131001
演講主題: Achilles heel – Strategy to Stop Human
Papillomaviruses in Their Tracks
摘要:
Human papillomaviruses (HPVs) are a large family of prevalent
pathogens, causing hyperproliferation of cutaneous and mucosal
epithelia, commonly known as warts. Persistent Infections by the
high-risk HPV-16, HPV-18 and closely related types can progress to
high grade lesions and cancers, such as cervical, penile, anal,
and laryngeal cancers, as well as a fraction of other head and
neck cancers. Prophylactic vaccines effectively prevent infections
by 4 virus types but do not cure pre-existing infections.
Therapeutic agents are urgently needed. Genetic studies of these
viruses are hampered because these viruses cannot be propagated in
conventional cell cultures. Rather, the productive phase depends
on proper squamous differentiation. We have developed an
organotypic skin culture system of primary human keratinocytes to
recapitulate a robust viral life cycle, permitting genetic
analyses of viral genes. Combined with our investigation of the
mechanisms that regulate viral DNA replication and amplification,
we have identified Achilles heel to control virus infection.
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