→ thomasjr:老師真好 耶QQ 01/08 09:53
推 battlee:賺P幣狗ˇˇ 01/08 12:29
推 shoujay:以後我也要來賺= = 01/08 17:16
→ thomasjr:屁 打這很辛苦ㄟˇˇ 01/09 12:59
推 YoyoBlue:樓樓上是舒潔?! 01/25 15:22
1.Please describe at least two stages of HIV-1 replication cycle in which antiviral
drugs can be designed for therapeutic purpose and list the types of drugs
currently in use?
1.reverse transcriptase inhibitor: Efavirenz
2.protease inhibitor: Indinavir
3.fusion inhibitor: Enfuvirtide
2.Please describe how bacteria, viruses and tumors (pick one to answer) can
evade host immune responses.
a.virus
HCV: block PKR, 使IFNα/β功能失效
HSV: 阻斷TAP傳遞peptide,阻擾antigen presentation
CMV, Adendovirus: 使MHC class I downexpression, 阻擾antigen presentation
CMV, HIV, measles: 使MHC class II downexpression, CD4 cell 減少
influenza virus: continuos antigen change
b.bacteria
secret protease to cleave secretory IgA dimers
production of surface structure to inhibit phagocytosis(M protein
polysaccharide capsule)
secret elastase to inactivate C3a C5a
secret hyaluronidase to enhance invasiveness
c.tumor
anti-tumor antibody enhance tumor growth
antibodies can modulate tumor antigens
tumor cells express low level of MHC class I
tumor cells provide poor co-stimulatory signals
3.Cancer formation is a multi-step process. Please give examples for three
categories of cancer-associated genes.
1.cell proliferation: myc ras
2.tumor supressor gene: p53 Rb APC
3.programmed cell death: bcl-2
--
※ 發信站: 批踢踢實業坊(ptt.cc)
◆ From: 163.25.118.143