※ 引述《white (蔡依林門票400/張)》之銘言：
: 志安的p.5 & p.7
: 似乎是皆不在此次範圍內
: 所以他去問了去年的考題(但我不知道有沒有重覆)
: 並且寫了解答~
: 明天會傳給我^^ 我再放上來跟大家分享
: 記得隨時注意一下本版有無新文章喔
ㄟ...雖然有點遲 已經考完了
不過我現在有機會用到lab電腦
還是把學長寫的部份po上來
給大家複習一下好了XD (逃~)
張富雄 重點整理 林志安
财 訊息傳遞方式
a .contact-dependent
b. paracrine c. synaptic d. ednocrine
财 Receptor 種類:
a. ion-channel-coupled receptors
b. G protein-coupled receptors(GPCR)
c. receptor tyrosine kinases(RTK)
d. cytokine recepotrs
e. nuclear receptors
财 Family of ligand-gated ion channels
a. Transmitter-gated Ion channels
b. Second messenger-gated Ion channels
财 Classes of G proteins
a. class I :Gs, Golf
b. class II : Gi, Go, Gt
c. class III: Gq
d. class IV: G12/13
财 Type I receptor superfamilies
a. Growth factor singaling
Insulin, epidermal growth factor(EGF)
Platelet-derived growth factor(PDGF)
b. Cytokine signaling
Erythropoietin, interferons, interleukins, growth hormone, leptin
c. TNF signaling
TNF-α , Fas
d. TGF signaling
TGF-β, BMP
财 Mode of actions of nuclear receptors
a. Steroid receptor:
Gucocorticoid receptor (GR)
Estrogen receptor (ER)
Progesterone receptor (PR)
Androgen receptor (AR)
Mineralcorticoid receptor (MR)
b. Non-steroid receptor
Thyroid hormone: TR
Vitamin D3: VDR
Retinoids: RAR, RXR
PPAR: PPAR, RXR
财 Signaling drugs
a. Small compounds: natural, synthetic
b. Peptidomimetics
c. Engineered proteins
d. Antibodies
e. Nucleic acids
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