→ hkchen: genetic factor + environmental factor-->oral cancer 06/21 23:47
推 chinchuan:End...，看不太懂.... 06/22 06:46
推 tien7644:筆記抄得很詳細耶~有些我根本來不及抄完的@@ 06/22 10:59
carcinogen/endogenous metabolism
1 DNA------------------------------->adducts-->genomic distability
->apoptosis/embryonic lethality(no cancer)
2 nuncleus DNA-->damage-->cell dysfunction
Mit.DNA-->damage-->quantity production of energy
3 mutation arise
- misincorporation during DNA system
- endogenous(UV,X-ray)/endogenous(replication error) damage
- insertionof mobile element
4 mutation repaired
- repair during or immediately DNA system
- direct reversal or by excision
5 DNA damage typing
a. single base changes
- transition and transversions
- deamination
b. indels and frameshifts
c. structural distortions
- UV irradiation
- alklation
- depurination,cross links
6. detective mutator-->genomic instability-->clonal progression
7. DNA repair system
- direct reversal repair
- excision repair
- mismatch repair
- recombination repair
- double strand break repair
- SOS repair
8. photoreactivation----DNA photolyase
methyl transferation----methyltranferase, removal of methyl group
9. genetic factor environmental---->oral cancer
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