[共筆] 藥理14勘誤

[lewdster0128 (熊)]

P13

框框內的Ethanol改成Methanol

小標題的Formepizole改成Fomepizole

p14

普拿疼在肝中代謝"需要"GSH的幫助

P19 第一行

基因通過細胞"膜"是基因治療的速率決定步驟

Q:有人問到喝到甲醇對人體造成傷害的到底是甲醛還是甲酸？

A:
Methanol is toxic by two mechanisms. Firstly, methanol (whether it enters the
body by ingestion, inhalation, or absorption through the skin) can be fatal
due to its CNS depressant properties in the same manner as ethanol poisoning.
Secondly, in a process of toxication, it is metabolised to formic acid (which
is present as the formate ion) via formaldehyde in a process initiated by the
enzyme alcohol dehydrogenase in the liver. The reaction to formate
proceeds completely, with no detectable formaldehyde remaining. Formate is
toxic because it inhibits mitochondrial cytochrome c oxidase, causing the
symptoms of hypoxia at the cellular level, and also causing metabolic
acidosis among a variety of other metabolic disturbances. Fetal tissue
will not tolerate methanol.

所以是甲"酸"，他會抑制細胞色素C氧化酶，造成細胞缺氧的症狀，也會造成acidosis。

補充：

甲醇中毒的話補充葉酸可以促進甲酸的排泄！

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有其他問題可以再跟我聯絡~

祝大家藥理考試順利~!


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推 Richard77523:你要留聯絡方式和基本資料啊!...
推 sinrong:感謝 真˙神庸
推 twbestman:那造成視力受損的是甲醛還是甲酸呢?
→ lewdster0128:你覺得勒~?
推 cidking:甲醛吧 化學活性比較大
→ lewdster0128:那我選甲酸好了~XD
推 cidking:還真的是耶 XD