推 ftsymoon:推 01/09 14:33
我有上網稍微搜尋一下
然後找到別人的期刊
Abstract. Calcium channels are essential for excitation-contraction coupling
and pacemaker
activity in cardiac myocytes. While L-type Ca2+ channels (LCC) have been
extensively studied,
functional roles of T-type channels (TCC) in native cardiac myocytes are
still debatable. TCC
are activated at more negative membrane potentials than LCC and therefore
facilitate slow
diastolic depolarization in sinoatrial node cells. Recent studies showed that
selective inhibition
of TCC produced a marked slowing of the pacemaker rhythm, indicating that
contribution of
TCC to cardiac automaticity was relatively larger than what had been
speculated in previous
studies. 所以我覺得答案是A啦To re-evaluate TCC, we measured current density and kinetics of TCC
in sinoatrial node
cells of various mammalian species. Current density of TCC was larger in mice
and guinea pigs
than in rabbit and porcine sinoatrial node cells. Interestingly, few or no
obvious TCC were
recorded in porcine sinoatrial node cells. Furthermore, it was demonstrated
that TCC could be
enhanced by several vasoactive substances, thereby increasing spontaneous
firing rate of
sinoatrial node cells. TCC may, at least in part, account for different heart
rates among various
mammalian species. In addition, TCC might be involved in physiological and/or
pathophysiological
modulations of the heart rate.
--
◢█◣ ◢█◣ ██◣ ◢█◣ ◢█◣ ██◣ ███ ███ █◣█
█▆▆ █ █ █ █ █▆█ █ ▅ █▆█ █▆▆ █▆▆ ███
▆▆◤ ◥█◤ ███ █ █ ◥█◤ █◥◣ █▆▆ █▆▆ █◥█
這個夏天
我們都在等
－蘇打綠 【::SoDaGreen::】
--
※ 發信站: 批踢踢實業坊(ptt.cc)
◆ From: 59.126.47.240