[內泌] 考古題

[h2ojen (水)]

P.27   第九題

我之前解考古題的時候，不小心多解了兩題
這是我查到的資料,我不知道選(E)會不會比較合適

1. http://ndt.oxfordjournals.org/cgi/content/abstract/13/5/1183
for example, it is known that LDL exhibits heterogeneity, with small dense
LDL III particles being more atherogenic.
意思就是LDL有分幾種種類，LDL I 是比較大的，
LDL III就是所謂的small density LDL，也是目前公認最具有atherogenic的

2. Galeano, N. F., M. Al-Haideri, F. Keyserman, S. C. Rumsey, and R. J.
   Deckelbaum. J. Lipid Res. 1998.

We hypothesize that small dense LDL might be more atherogenic than normal
size LDL due to decreased hepatic clearance by the LDL receptor, and enhanced
anchoring to LDL receptor-independent binding sites in extrahepatic tissues
(e.g., the arterial wall), a process mediated, in part, by cell surface
proteoglycans. Small dense low density lipoprotein has increased affinity
for LDL receptor-independent cell surface binding sites: a potential mechanism
for increased atherogenicity.

sorry...排版的很亂>.<

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