→ joxu:感謝陳同學:) 06/21 00:39
p.23 #11 (同p.19 #11)
這題很狠喔 老師沒教就sudden death了
11. 父母的任何一方為家族性結腸息肉症患者，則其子女罹患機率為
ANS: (C)50%
詳解：http://ghr.nlm.nih.gov/condition/familial-adenomatous-polyposis
When familial adenomatous polyposis results from mutations in the APC gene,
it is inherited in an autosomal dominant pattern, which means one copy of the
altered gene in each cell is sufficient to cause the disorder. In most cases,
an affected person has one parent with the condition.
When familial adenomatous polyposis results from mutations in the MUTYH
gene, it is inherited in an autosomal recessive pattern, which means both
copies of the gene in each cell have mutations. Most often, the parents of an
individual with an autosomal recessive condition each carry one copy of the
mutated gene, but do not show signs and symptoms of the condition.
所以總共有四種情況
APC mutation - 體聯顯性
1) AA x aa 100%
2) Aa x aa 50%
MUTYH mutation - 體聯隱性
3) aa x Aa 50%
4) aa x AA 0%
所以答案還是50% ya!!!
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