推 a939253 :謝謝! 10/30 18:31
前陣子有人看到免四No.4共筆內容
來問我
30s ribosome subunit inhibitor不都是殺菌類藥物嗎?
老師在09/26上課時的確這樣說，
在09/27講aminoglycoside時，說aminoglycoside毒性強，屬殺菌類。
但10/03講Tetracycline時，只說這類是30s ribosome subunit inhibitor，
沒說他屬於殺菌還是抑菌類。
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我前幾天寄信去問老師，
以下是老師回信：
對不起！我上課好像說的不清楚。
in Basic & Clinical Pharmacology, 12e
“Tetracyclines are broad-spectrum bacteriostatic antibiotics that inhibit protein synthesis.”
“Aminoglycosides & Spectinomycin are bactericidal inhibitors of protein
synthesis that interfere with ribosomal function. These agents are use
-ful mainly against aerobic gram-negative microorganisms.”
In Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e
“Tetracyclines are bacteriostatic antibiotics
with activity against a wide range of aerobic and anaerobic gram-positive
and gram-negative bacteria.
“In contrast to most inhibitors of microbial protein synthesis, which are
bacteriostatic, the aminoglycosides are bactericidal inhibitors of protein
synthesis.”
兩本國考用書都說明
Tetracycline類抗生素是抑菌類抗生素
Aminoglycoside類和Spectinomycin屬bactericidal agents!!
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所以要修改免四共筆No.2 p.3
4. I. 把為bacteriocidal類抗生素刪去
底下的Tetracycline 後面加上（bacteriostatic）
Aminoglycoside後面加上（bactericidal）
另外在同一頁還有一個錯誤
5. Sulfonamide抑制的酵素改成dihydropteroate synthetase
底下補上葉酸合成步驟：
Dihydropteroic
PABA────────→ acid -──────→ DHFA -──────→ THFA
Dihydropteroate Dihydrofolate Dihydrofolate
synthetase synthetase reductase
免四學藝 景仲 罡妹
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※ 編輯: yayaorz 來自: 111.253.77.9 (10/30 16:18)