※ 引述《fr375224 (紫嵐)》之銘言：
: 想問一題有機合成
: 請問要如何從乙炔開始製備成 ＿
: ／ ＼
: ╲Ｏ╱＼
: ＣH3
: 謝謝了@@
:
1.Protect ethylene diol at one end with silyl group
2.Transform the other hydroxy group to bromide or what ever good leaving groups
3.Deprotonate acetylene with MeLi and take this anion to react with 2.
4.Deprotect silyl group with KF and reduce C三C to C=C (ex. NH3,Na)
5. a.Hg(OAc)2 b.NaBH4, NaOH (Cyclize at internal carbon)
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◆ From: 205.237.164.247
※ 編輯: allenehongn 來自: 205.237.164.247 (01/10 12:21)