[Ask ] Why would the anti-inflammatory drug cause ulcer

[fizeau (.)]

I've read a news article about Barbara Bush, a former first lady of
the United States, who underwent a surgery to fix her perforated
duodenum ulcer.

It's suspected that the anti-inflammatory drug could cause this--
uncommon but not unheard of.

Why is that? What is the likely mechanism of it?

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推 Bigfatty73:most NSAIDS (Non Steroidal Anti Inflammatory Drugs)
→ Bigfatty73:are COX (Cyclooxygenase) inhibitors
→ Bigfatty73:There are 2 dominant COX forms (human) COX1; COX2
→ Bigfatty73:in short, COX1 is responsible for blood/mucosal
→ Bigfatty73:regulation, COX2 is for Inflammation
→ Bigfatty73:-------------------------------------------
→ Bigfatty73:So why not just inhibit COX2 ?
→ Bigfatty73:at 2004, a COX2 specific(~30 fold)inhibitor Vioxx
→ Bigfatty73:was recalled from the market, no patients had ulcer
→ Bigfatty73:but almost half suffered myocardial infarction...
推 Bigfatty73:Merck, was hurt bad
→ formec:the more you are saying , the more vague I fell. XD
推 Bigfatty73:okay my wrong.  The most popluar anti inflammatory
→ Bigfatty73:is catagorized as NSAIDS
→ Bigfatty73:It reduces both COX1 and COX2 in the body    ^drugs
→ Bigfatty73:If you need Pain relief, you only need to stop COX2
→ Bigfatty73:Instead, COX1 is affected as well, causing stomach-
→ Bigfatty73:problems
推 wnwangster:chemistry always does the trick better than count-
→ wnwangster:ing sheeps.