推 chen95982000:I admire ur sientific craziness. 12/26 22:25
→ chen95982000:what's ur major actually? 12/26 22:25
噓 terimakasih:just a sxxxbag flooding the board 12/27 16:40
The increase in triglyceride occurred several hours after the elevation
of plasma FFA levels and coincided with the development of insulin
resistance(10), suggesting that an insulin resistance-causing signal
was generated during the synthesis of TG.
We hypothesize that diacylglycerol may be such a signal because an
increase in its synthesis would coincide with that of triglycerides
and because it is a well-known allosteric activator of protein kinase
C(12-14), an enzyme that has been linked to insulin resistance
To evaluate this possibility, DAG mass and PKC activity and distribution
were assayed in skeletal muscle biopsies
Because PKC is known to activate NF-kB(20,21) and because NF-kB has
recently been linked to fatty acid-induced impairment of insulin action
, we have also examined the possibility that the development of insulin
resistance was related to alterations in the IKK/IkB/NFkB pathway.
In addition, the accumulation of ceramide, another lipid metabolite
linked to insulin resistance, was evaluated(24).
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