出處Merck Index
基本上跟原本的差不多
Monograph Number: 837
Title: Ascorbic Acid
CAS Registry Number: 50-81-7
CAS Name: L-Ascorbic acid
Additional Names: vitamin C; 3-oxo-L-gulofuranolactone;
L-threo-hex-2-enonic acid g-lactone; L-3-keto-threo-hexuronic acid lactone;
L-xylo-ascorbic acid; antiscorbutic vitamin; cevitamic acid
Trademarks: Ascorbicap (ICN); Ascorbicin (Bristol-Myers Squibb); Ascorvit
(Jenapharm); Cantan (Hoechst); Cebion (Merck KGaA); Cecon (Abbott);
Celaskon (Leciva); Celin (Glaxo); Cenolate (Abbott); Cereon (Teva);
Cetebe (Fink); Cevalin (Lilly); Ce-Vi-Sol (Mead Johnson); Cevitan (RPR);
Cewin (Sanofi Winthrop); C-Vimin (Astra); Hybrin (Pharmacia);
Laroscorbine (Roche); Lemascorb (Ascher); Redoxon (Roche); Ribena
(Reckitt & Colman); Vita C?(Chemedica); Vitacimin (Takeda); Vitacin
(Mect); Vitascorbol (Rhône-Poulenc)
Molecular Formula: C6H8O6
Molecular Weight: 176.12.
Percent Composition: C 40.92%, H 4.58%, O 54.51%
Literature References: Physiological antioxidant. Coenzyme for a number of
hydroxylation reactions; required for collagen synthesis. Widely distributed
in plants and animals. Most primates (including humans), guinea pigs, and
some birds and fish cannot synthesize ascorbic acid. Inadequate intake
results in deficiency syndromes such as scurvy. Dietary sources include
citrus fruits, potatoes, peppers, broccoli, cabbage, and rose hips. First
isolated from the adrenal cortex of ox and later from lemons and paprika
(originally called hexuronic acid): A. Szent-Györgyi, Biochem. J. 22, 1387
(1928); W. N. Haworth, A. Szent-Györgyi, Nature 131, 24 (1933). Structure
studies: R. W. Herbert et al., J. Chem. Soc. 1933, 1270. Synthesis: R. G.
Ault et al., ibid. 1419; T. Reichstein et al., Helv. Chim. Acta 16, 561, 1019
(1933); 17, 311, 510 (1934). Review of discovery, structure and synthesis:
E. L. Hirst, Fortschr. Chem. Org. Naturst. 2, 132-159 (1939). Crystal
structure: J. Hvoself, Acta Chem. Scand. 18, 841 (1964). Review of
syntheses: T. C. Crawford, S. A. Crawford, Advan. Carbohyd. Chem. 37, 79-155
(1980). HPLC determn in plasma: J. Lykkesfeldt et al., Anal. Biochem. 229,
329 (1995). Discussion of use in the treatment of the common cold: L.
Pauling, Proc. Nat. Acad. Sci. USA 68, 2678 (1971); H. Hemil? Scand. J. Inf.
Dis. 26, 1 (1994). Clinical applications in immunology, lipid metabolism and
cancer: Int. J. Vit. Nutr. Res. 1982, Suppl. 23, 294 pp. Comprehensive
description: I. A. Al-Meshal, M. M. A. Hassan, Anal. Profiles Drug Subs. 11,
45-78 (1982). Reviews: G. M. Jaffe in Kirk-Othmer Encyclopedia of Chemical
Technology vol. 24 (John Wiley & Sons, New York, 3rd Ed., 1984) pp 8-40;
"Vitamin C" in Vitamins, W. Friedrich, Ed. (Walter de Gruyter, Berlin, 1988)
pp 929-1001. Review of pharmacology and clinical applications: M. Levine,
N. Engl. J. Med. 314, 892-902 (1986); H. E. Sauberlich, Ann. Rev. Nutr. 14,
371-391 (1994).
Properties: Crystals (usually plates, sometimes needles, monoclinic system).
Pleasant, sharp acidic taste. mp 190-192?(some dec). d 1.65. [a]D25 +20.5
to +21.5?(c = 1 in water); [a]D23 +48?(c = 1 in methanol). pH = 3 (5 mg/ml);
pH = 2 (50 mg/ml); pK1 = 4.17; pK2 = 11.57. uv max at pH 2: 245 nm (E1%1cm
695); at pH 6.4: 265 nm (E1%1cm 940). Redox potential (first stage): E10
+0.166 V (pH 4). One gram dissolves in about 3 ml water, 30 ml alc, 50 ml
abs alc, 100 ml glycerol, 20 ml propylene glycol. Soly in water: 80.0% at
100? 40.0% at 45? Insol in ether, chloroform, benzene, petr ether, oils,
fats, fat solvents. Strong reducing agent. Stable to air when dry; aq solns
are rapidly oxidized by air.
Melting point: mp 190-192?(some dec)
pKa: pK1 = 4.17; pK2 = 11.57
Optical Rotation: [a]D25 +20.5 to +21.5?(c = 1 in water); [a]D23 +48?(c = 1
in methanol)
Absorption maximum: uv max at pH 2: 245 nm (E1%1cm 695); at pH 6.4: 265 nm
(E1%1cm 940)
Density: d 1.65
Derivative Type: Calcium hypophosphite
Additional Names: Asphocalcium
Trademarks: Calscorbat (l'Aerocid)
Molecular Formula: C6H9CaO8P
Molecular Weight: 280.18.
Percent Composition: C 25.72%, H 3.24%, Ca 14.30%, O 45.68%, P 11.06%
Derivative Type: Calcium salt
CAS Registry Number: 5743-27-1
Additional Names: Calcium ascorbate
Molecular Formula: C12H14CaO12
Molecular Weight: 390.31.
Percent Composition: C 36.93%, H 3.62%, Ca 10.27%, O 49.19%
Literature References: Prepn: Ruskin, Merrill, Science 105, 504 (1947).
Properties: Dihydrate, triclinic crystals, [a]D20 +95.6?(c = 2.4). Freely
sol in water. Practically insol in methanol, ethanol.
Optical Rotation: [a]D20 +95.6?(c = 2.4)
※ 引述《zitotw (那個人)》之銘言：
: → maginot:http://www.nsc.gov.tw/files/popsc/2006_118/52-57.pdf 11/12 23:22
: 推 karuwolf:推薦！ 11/13 19:32
: 推 ckriley:其實左旋右旋的測定原理與光偏振有關. 11/13 20:31
: 其實看了那個網址，我一開始覺得可信度不夠
: 畢竟他隨便引了個數據說 [α]18<>D<> = +19.2°
: 連詳細出處都沒說，只說是94 年臺南區科展數據
: 實在很令人惶恐
: 去網路上查，卻又是眾說紛紜
: 眾說中，看不到實驗數據
: 紛紜裡，旋光度似乎根本不被重視，正式的資料中都沒有這個項目
: 勉強找到了兩個網站，結果是符合原連結中的說法，一般的維生素Ｃ是右旋的（＋）
: http://www.jtbaker.nl/bin/prod_gevonden.ASP?zoekprodnr=1914&language=EXP
: http://www.kicgroup.com/ascorbic.htm
: 大家就姑且看看吧
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