國家理論科學研究中心學術演講
2009 NCTS Seminar on Statistics
Speaker: Professor Kuo-Bin Li 李國彬
(National Yang-Ming University)
Time: Friday, Oct. 23, 2009
(1)11:30 am-1:00pm, group meeting
(2)1:00-2:30pm, seminar
Topic: Applying Computational Sequence Analysis to
MicroRNA-mediated Gene Regulation
Abstract:
MicroRNAs are small noncoding RNAs that are predicted to regulate the
expression of approximately one-third of all human genes. This regulation
occurs post-transcriptionally through miRNA binding to mRNA targets leading
to subsequent target degradation or inhibition of translation. I will focus
on three bioinformatics applications to miRNA-mediated gene regulation. In
the first application, the dysregulation of miR-224 was shown to be related
to hepatocellular carcinoma. To identify the putative target genes of
miR-224, we developed a computational filtering system that aims to reduce
the number of false positive predictions.
Experimental biologists often select convincing putative target genes based
on the observation of negative correlation in miRNA/mRNA expression
profiles. To investigate the effectiveness of this strategy, we also
conducted a systematic survey on the correlation between miRNA and mRNA
expression profiles using data generated from NCI-60 cancer lines.
Comparisons between commonly used target prediction software will be
presented.
Place:
交通大學綜合一館427室
--
※ 發信站: 批踢踢實業坊(ptt.cc)
◆ From: 140.113.114.205