※ [本文轉錄自 NCTU-STAT98G 看板 #1DfiP7OV ]
作者: MoshiX2 (阿威) 看板: NCTU-STAT98G
標題: [演講] 4/15(五) 統研所專題演講 (清大)
時間: Thu Apr 14 18:02:45 2011
題 目: Primate Genome Evolution - How Different Are We from the Apes?
主講人: 陳豐奇 博士 (國家衛生研究院 群體健康科學研究所)
時 間: 100年4月15日（星期五）上午 10:40 - 11：30
（上午10：20- 10：40茶會於統計所821室舉行）
地 點: 清大綜合三館837室
Abstract
Human phenotypes usually have their evolutionary origins. By comparing the
genomes between human and other model organisms, we may gain insights into
the genetic backgrounds from where human-specific traits emerge. In this
presentation, I will discuss the divergences between human and other model
organisms and their biological implications. Particularly, the human genome
contains a surprisingly large number of species-specific insertions and
deletions that affect such biological functions as
transcriptional/translational regulations and viral life cycle. Some of these
genetic changes, possibly due to their importance in human adaptation, are
subject to positive selection. Meanwhile, human also differs from other
organisms at the transcriptome level. By examining the processed pseudogenes
of human and chimpanzee, we were able to trace the evolutionary history of
the ancestral human transcriptome and identify lineage-specific loss of
exons. We found that even between such closely related species as human and
chimpanzee, transcript structures may have changed considerably. The
divergences between human and other primates are thus multi-layered and more
complex than we previously recognized.
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