Beta-catenin stabilization extends regulatory T cell survival and
induces anergy in nonregulatory T cells
這是2008.2在nature medicine所發表的文章
abstracts:
Beta-catenin is a central molecule in the Wnt pathway. Expression of a
stable form of beta-catenin on CD4+CD25+ regulatory T cells resulted in
a marked enhancement of survival of these cells in vitro. Furhtermore,
stable beta-catenin-expressing CD4+CD25+ Treg cells outcompeted control Treg
cells in vivo, and the number of Treg cells necessary for protection against
inflammatory bowel disease could be substantially reduced when stable
beta-catenin-expressing CD4+CD25+ Treg cells were used instead of control
Treg cells.
Expression of stable beta-catenin on potentially pathogenic CD4+CD25+ T cells
rendered these cells anergic, and the beta-catenin-mediated induction of
anergy occurred even on Foxp3-deficient T cells. Thus, through enhanced
survival of existing regulatory T cells, and through induction of unresponsive-
ness in precursors of T effector cells, beta-catenin stabilization has a power-
ful effect on the prevention of inflammatory disease.
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