Intern Seminar考題
First Part VS 簡穎秀 by Ri林其懋
(E) 1. 關於唐氏症的敘述，下列何者為非
(A) 唐氏症病患除了會有智能障礙，發展遲緩的問題以外，還可能會有過動，具攻
擊性等行為問題，以及重度憂鬱等心理問題
(B) 幾乎所有唐氏症病患到了成年(30-40歲)都會有類似Alzheimer disease的神經
病變
(C) 唐氏症病患剛出生的時候，腦子結構跟正常嬰兒並沒有明顯的差異。智能障礙
的發生主要是因為在成長的過程中，腦部逐漸發生退化的緣故
(D) Chromosome 21上的q22區域被認為跟許多唐氏症病患的許多特徵(如智能障礙，
先天性心臟病，特殊臉型)很有相關。
(E) 以上皆對
(E) 2. 關於唐氏症智能障礙的治療，下列何者為非
(A) 非特異性治療方面包括營養治療，荷爾蒙治療，和早療。早療對智力發展的幫
助不大，但對運動技能和社交能力有一定程度的幫忙
(B) Acetylcholinesterase inhibitor可以提升腦中的Acetylcholine；Selective
serotonin-reuptake inhibitor可以提升腦中的serotonin，兩者都有助於唐
氏症病患腦部的發育
(C) 過量的glutamine刺激會過度活化NMDA receptor，對神經細胞產生毒害，因此
NMDA antagonist有助於減少唐氏症病患腦部的破壞
(D) Minocycline和COX-2 inhibitor可以減緩唐氏症病患腦中過強的發炎反應，減
少腦部的破壞，達到保護的目的
(E) 以上皆對
(E) 3. 關於神經性疾病的基因治療，下列何者為非
(A) Adenovirus，adenoassociated virus，lentivirus，以及liposomes是最常用
的載體，可以將基因帶入神經細胞中
(B) Lentivirus是RNA virus，它引發的宿主免疫反應很小，但卻有致癌的可能性
(C) Adenovirus是DNA virus，它會引發較強的宿主免疫反應，因此比較沒辦法讓轉
過去的基因長期表現
(D) Adenoassociated virus是DNA virus，不同的serotype喜歡感染不同的神經細
胞，例如AAV5喜歡感染小腦的Purkinje cells而不會感染granular cells
(E) 以上皆對
(E) 4. 關於RNA interference，下列何者為非
(A) RNA interference是一種用來抑制特定基因表現的技術，它把特定基因的double
-stranded RNA homologous打入細胞中，就能有效抑制抑制特定基因的表現
(B) 這種技術最早是1998年在C. Elegans上發現的。本來以為無法用在哺乳類細胞上
面，但後來發現只要將dsRNA縮小成21-22 nucleotides (稱為 small interfer-
ing RNA, siRNA)就能避免哺乳類細胞對dsRNA產生免疫反應，從而應用在哺乳類
細胞上
(C) 科學家將siRNA做成fold-back stem-loop的結構，稱為short hairpin RNA(shRNA
)，可以大大加強該技術抑制基因表現的時間和穩定度
(D) 利用RNA interference來抑制唐氏症病患過量的基因表現，是未來治療唐氏症的
一個方向
(E) 以上皆對
Second Part VS 楊曜旭: by Ri 陳銀君
(B) 1.There are many health benefits from lactobacillus or Bifidobacterium in recent studies. Which is NOT reported formally in the following choices?
(A) preventing irritable bowel syndrome (B) curing cancer
(C) reducing atopic dermatitis (D) enhance bacteria clearance of lung.
(D) 2.In the article “oral treatment with life Lactobacillus reuteri(LR) inhibits the allergic airway response in mice”, which choice is NOT noted?
(A) circulatory eosinophils can be reduced after LR added
(B) OVA + LR reduce airway inflammation
(C) Treatment of LR significantly attenuated the increase in MCP-1, TNF,
IL-5 and IL-13.
(D) heat-killed or gama-irradiated LR also can modulate airway inflammation
response.
(A) 3. In the article “oral treatment with life Lactobacillus reuteri(LR) inhibits the allergic airway response in mice”, which choice is NOT including in attenuating allergic airway response?
(A) L. salivarians (B) LR (C) TLR-9 (D) IDO activation.
By Ri 蔡萬全
(A) Which of the following is false?
A. The preventive effect of probiotics on infant eczema was well
established and no further research was needed.
B. An altered microbial exposure may be partly responsible for the
increase of allergic diseases in populations with a western lifestyle.
C. Probiotics have been reported to improve the symptoms in infants with
eczema in a recent study.
D. Different probiotic strains might have different properties critical
for an effect on allergic diseases.
By Ri 林奕辰
(A) 1. 關於“A live microbial food supplement with a proved beneficial effect on human health.” 是以下何者的定義？
(A) probiotic
(B) prebiotic
(C) antibiotic
(D) antipsychotic
(B) 2. 懷孕期至嬰兒早期，嬰兒體內cytokine是以下列何者為主？
(A) TH1 humoral immune
(B) TH2 humoral immune
(C) TH3 humoral immune
(D) 以上皆非
(D) 3. 下列何者非probiotic？
(A) Bifidobacterium longum
(B) Bifidobacterium infantis
(C) Lactobacillus rhamnosus
(D) E. coli
(D) 4.大部分腸道菌叢以下列哪一種receptor與腸道epithelium interaction？
(A) complement receptor
(B) chemokine receptor
(C) hormone receptor
(D) Toll like receptor
(C) 有關 ”Hygiene hypothesis” 及probiotic的臨床研究中證實，給予probiotic可減少哪一種atopic disease的發生？
(A) asthma
(B) allergic rhinitis
(C) atopic eczema
(D) food allergy
Third Part VS 陳慧玲: By Ri 陳宜明
(e) 1.Which statement is wrong about Alagille syndrome?
a. A dominant inherited multisystem disorder
b. The incidence is 1 per 100,000 live births
c. Involved mutations in Jagged1 gene
d. The phenotype presentation shows a great variety in severity
e. Liver transplantation is indicated in a majority of patients
(b) 2.Which of the following descriptions is not common characteristics of Alagille syndrome?
a. Bile duct paucity
b. Broad forehead; deep-set, widely-spaced eyes; and an over-developed
mandible
c. Posterior embryotoxon
d. Peripheral stenosis of the pulmonary artery
e. Butterfly-like vertebral-arch defects
(b) 3. Which statement is wrong about liver transplantation in children with Alagille syndrome?
a. Clear criteria are difficult to establish in clinical practice
b. Post-op complications included acute graft rejection, vascular
complications, Infections, ascites, diaphragmatic hernia, and
hypercholesterolemia
c. Common vascular complications included portal vein thrombosis,
mid-aortic syndrome, and arterial bleeding.
d. There were more post-transplant bleeding complications in patients
with Alagille syndrome than in those with other diagnosis
e. Control post-transplant arterial hypertension carefully or performing
preoperatively angiographic evaluations can prevent bleeding
complications.
By Ri 葉芷圻
(D) 1. Algille's syndrome ( arteriohepatic dysplasia ) 下列哪個不正確?
A) Intrahepatic bile duct atresia
B) JAG1 gene mutation
C) D-bilirubin升高
D) 大便顏色正常, 可以和biliary atresia區分
(A) 2. Extrahepatic biliary atresia 的孩子手術術式應該選擇:
A) Kasai operation
B) Cesarean section
C) Orchypexy
D) Blalock-Taussig Shunt
(C) 3. Ectrahepatic biliary atresia 開完刀的預後和下列何者比較無關?
A) bile stasis的程度
B) inflammation process
C) EKG的finding
D) JAG1 mutation 的有無
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