Among the following statements about the molecular and chromosomal
pathology of neuroblastoma, which one is most incorrect?
(A) Amplification yields more copies of MYCN than duplication does.
(B) Negative MYCN amplification is a favorable prognostic factor
only in stage 1-3 and 4s disease.
(C) In addition to the increase in gene dosage, deletion might also
contribute to the oncogenesis of neuroblastoma.
(D) Tumors with high concentration of neurotrophin receptors such
like TRKA & TRKB often show spontaneous regression.
Ans. (D)
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