Re: 可不可以幫我解答

[Lipaty (月餅不要吃太多)]

※ 引述《YuChHa (偷心計畫)》之銘言：
: ※ 引述《cave (三毛貓：水深火熱)》之銘言：
: : in vivo 情況下，
: : mitochondria 藉由 "proton-motive force" 驅動 ATP synthase。
: : 因為 intermembrane space(外) proton conc. 高，matrix(內)
: : proton conc.低，外部的 proton 會經 ATP synthase 進入內部，
: : 此時利用 proton concentration gradient 儲存的化學位能，
: : 驅使 ATP synthase 合成 ATP。
: : 所以在 in vitro 情況下也相同，當外部 pH 低 (proton 濃度高)，
: : 可以促使 mitochondria membrane 上的 ATP synthase 產生 ATP。
: : 這題從結果現象反推：
: : 在肌肉劇烈運動或 mitochondria function 受損時，cell 會進行
: : lactic acid fermentation。由此推測，這個新藥可能造成
: : mitochondria DNA 的損壞，於是 electron-carrier complexes 失
: : 去正常功能，electron transport chain 無法正常進行，最後細胞
: : 不能 uptake oxygen，細胞在缺氧狀態下，只好進行 lactic acid
: : fermentation。
: : "drastic overproduction of lactic acid and liver failure"就
: : 這樣產生了。
: : (ps 不曉得有沒有說錯的地方 以上是不負責任版 :p)
: 網路上看到的!!
: The key concept is that lactic acid is produced only when there is exertion
: for the muscles or when mitochondrial function is inhibited.
: The drastic overproduction of lactic acid and liver failure due to a drug
: that acts like a nucleotide would only occur if this analogue was
: incorporated into mitochondrial DNA, disrupting mitochondria function.
: Tragically, that is exactly what happened in this case.
: The overproduction of lactic acid is evidence that
: fermentation is occuring on a large scale.
: Knowing that the drug can interfere with DNA replication,
: it makes sense to conclude that it has interefered with mitochondrial
: DNA and affected normal ATP production.
: If the mitochondria's ability to produce ATP were disrupted,
: the ATP would have to be produced outside the mitochondria,
: by fermentation taking place in the cytosol.
: Though it is normal for the body to use fermentation,
: especially by muscle cells during hard excercise,
: fermentation is a temporary response that cannot be sustained in humans.
: In the case of patients in this clinical trial,
: ongoing exposure to the drug would disrupt mitochondrial DNA as use continued,
: rendering more mitochondria unable to produce ATP.
: Lactic acid production as a by-product of fermentation would continue,
: and eventually overwhelm the liver.
      ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
      位什麼不會是全身性的?

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推 potty:雖然不很清楚 但肝炎藥應該對肝有特異性吧
推 Lipaty:會有特異姓嗎? 肝臟特別會uptake這個藥喔?
推 cave:利用"藥物釋放"的特異性應該可以辦得到
推 YuChHa:拜託  肝臟是代謝什麼的!!
推 YuChHa:其實我也不知道唷!!><
→ Lipaty:是代謝什麼的? 生科系畢業學弟?
推 YuChHa:我只知道肝臟好像會用來分解醋酸
→ YuChHa:我很遜唷  錯了不要罵我  @@
推 Lipaty:醋酸, 所以與本題的關係是?
推 YuChHa:我打錯了  我要說的是乳酸!!
→ YuChHa:聽說一下子太多乳酸  肝臟會水腫!!
噓 Lipaty:那這個跟藥物再肝臟的特異性有什麼關係咧?
推 Lipaty:本提好像沒有答案