Re: 免疫整理6

[deathscytheX (° ▽ °|||)]

※ 引述《deathscytheX (° ▽ °|||)》之銘言：
恕刪

Allelic exclusion refers to the fact that in a heterozygous individual, only
one of the alternative C-region alleles of the heavy or light chain is
expressed in a single B cell and in an immunoglobulin molecule. The term has
come to be used more generally to describe the expression of a single
receptor specificity in cells with the potential to express two or more
receptors.

怎麼跟共筆不一樣╭(─╴╴─)╮

這是課本的解釋

是共筆寫錯還是老師講錯

請各位醒著且沒翹課的check一下XD

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◆ From: 61.228.186.166
推 BLACKOA:有錯嗎?課本260頁也可以看看
→ BLACKOA:你的說法就是再強調他只表現其中一個allele..
→ BLACKOA:而我那個是已經細講了(實際是靠pre-B receptor)
→ deathscytheX:其實不太一樣
首先

課本上那個實驗不能解釋你說的東西

只能解釋我貼上的那些

而所謂Allelic exclusion是從那個實驗看到的現象

其二

Allelic exclusion的機制到現在還有paper在討論

並不是共筆說的那樣

舉個例子

Allelic exclusion of the TCR alpha-chain is an active process requiring
TCR-mediated signaling and c-Cbl.
J Immunol. 2003 May 1;170(9):4557-63.

不知道你暸不了解我的問題

我沒課本，不知道你說的那一頁在哪XD

不過我猜你是要我看以下這一段吧XD
The RAG-1:RAG-2 dimer is a component of
the V(D)J recombinase (see Section 4-5) which is active at very early
stages of lymphoid development. In both B- and T-cell lineages there is a
later and temporary suppression of RAG gene expression after successful
rearrangements have been completed at the first of the two rearranging
loci

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※ 發信站: 批踢踢實業坊(ptt.cc) 
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推 BLACKOA:哈哈...你猜錯了....