→ deathscytheX:我support我們原本的想法140.112.133.225 05/26
※ 引述《TianKongLan (躺著的幸福...不想起來..)》之銘言：
Fig. 2. The influenza entry pathway. Influenza viruses bind to receptors
containing sialic acid on the cell surface. Virus particles are then endocytosed
and enter early endosomes. Subsequently, the viruses are trafficked to
late endosomes, where the low pH triggers viral fusion.Viral ribonucleoproteins
(vRNP) escape into the cytosol and are imported into the nucleus,
where replication occurs.
Microbes Infect. 2004 Aug;6(10):929-36.
Endocytosis of influenza viruses.Endocytosis of influenza viruses.
Lakadamyali M, Rust MJ, Zhuang X.
看了這篇 還有下面這篇introduction的部分
Structured model of influenza virus replication in MDCK cells
Biotechnol Bioeng. 2004 Oct 5;88(1):1-14.
Sidorenko Y, Reichl U.
2篇主要在說viral進入host cell的pathway 機制第2篇的比較清楚
裡面都題到 receptor-mediated endocytosis,所以我想我們上次的結論還是對的
binding-->endocytosis--->endosome形成--->low pH which activates viral M2
ion channels and allows protons to enter the interior of the virus particle.
之後M2 conformation change 還有acid-catalyzed conformational rearrangements
of HA proteins.接著 才有fusion的動作 release vRNPs.
至於助教說的哪各地方 的定義 我想這樣應該清楚了
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