推 asami:感激不盡T^T 03/28 10:02
→ asami:是說D大~~~Micromedex真是好物~(遠望) 03/28 10:06
※ 引述《doctoja ( )》之銘言：
: ※ 引述《asami (喜歡浩秀not湖水)》之銘言：
: : as title
: : 如果要loading Depakine或Dilantin的話
: : 學姐們會在bag裡面稀釋多少水??然後給多少的速度??
: : 我的師父教我→Depakine大概是100ml然後給200ml/hr的速度
: : Dilantin比較容易allergy~所以速度可以慢一點
: : 單位資深學姐→loading這類的藥物滴速應該要快一點
: : 因為第一次的loading是為了增加體內濃度的這樣
: : 所以Depakine應該是50ml然後給500ml的速度
: : 不過因為Dilantin容易alergy~所以也是說速度可以慢一點
: : 請問到底哪個才對啊????
: : 藥典只有提到他T1/2跟代謝機轉之類的
: : 沒講到給藥速度耶~~@@"
: : 先謝謝回答我的學姐喔!!感激不盡啊!!
: 查了micromedex
: #Dilantin
: Intravenous
: (adults) max infusion rate 50 mg/min
: (neonates) max infusion rate 1 to 3 mg/kg/min (max 50 mg/min)
: avoid continuous infusion
: flush line with saline following infusion to avoid local venous irritation caused by alkalinity of solution
: inject directly into a large vein through a large-gauge needle or IV catheter
: #Depakine
: A suggested dose to begin therapy in adults is up to 10 mg/kg by intravenous
: injection over 3 to 5 minutes followed by intravenous infusion, as necessary,
: up to a maximum of 2.5 g daily. The usual intravenous dose for children is
: in the range of 20 to 30 mg/kg daily. If doses in excess of this are required
: , plasma-valproate concentrations must be monitored, and if the dose exceeds
: 40 mg/kg daily, clinical chemistry and haematological parameters should also
: be monitored.
總結一下:
Status epilepticus: 10-15 mg/kg IV loading dose (not to exceed 50 mg/min),
followed by maintenance doses of 100 mg ORALLY OR IV every 6-8 hr
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