流病所與預醫所聯合演講會通知
時 間：93 年 6 月 15 日(星期二) 12：30-13：30
地 點：基醫大樓 1536 講堂
主講人：謝叔蓉 副研究員 (中央研究院 統計科學研究所)
題 目：Reconstructing Gene Networks by A Data-driven Response Surface Method
摘 要：Xu et al. (2000) introduced an interesting response surface model to
reconstruct gene networks from microarray data. However, the fixed
surface approach failed to find meaning Activator-Repressor-Target
Gene triplets in Yeast data sets (Spellman et al., 1998). We proposed
a data-driven response surface model. The innovation is two-fold:
1. the surface is constructed by data and
2. it allows a time-lag for the activator and repressor genes to act
on the target gene.
Using the alpha Yeast data set, part of the networks reconstructed
are consistent with existing biology knowledge. While some novel
parts are yet to be verified by RT-PCR.
Those networks that are consistent with annotated biology knowledge
are as follows: RAD50 represses SGS1 SOD1 activates TOP1, SAE2
represses RAD51 and rAD51 in turn represses RAD24 and RAD54 represses
RAD24.
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