推 stanlyleu:病毒性肝炎會使用阿 12/13 15:44
Reviews上提到了interferon
一般在臨床上,會給這類的藥物當作抗病毒使用嗎?
也順便問一下現在使用的一些蛋白質藥物? 有已經成熟的嗎?
Interferons at age 50: past, current and
future impact on biomedicine
The family of interferon (IFN) proteins has now more than reached
the potential envisioned by early discovering virologists: IFNs
are not only antivirals with a spectrum of clinical effectiveness
against both RNA and DNA viruses, but are also the prototypic
biological response modifiers for oncology, and show effectiveness
in suppressing manifestations of multiple sclerosis. Studies of
IFNs have resulted in fundamental insights into cellular signalling
mechanisms, gene transcription and innate and acquired
immunity. Further elucidation of the multitude of IFN-induced genes,
as well as drug development strategies targeting IFN production
via the activation of the Toll-like receptors (TLRs), will almost
certainly lead to newer and more efficacious therapeutics.
Our goal is to offer a molecular and clinical perspective that
will enable IFNs or their TLR agonist inducers to reach their
full clinical potential.
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