推 lasixchueh:哇!我第一次聽過A酸用來長期使用,還拿來預防微小粉刺的 12/21 14:53
→ lasixchueh:請問您的論點,有什麼文獻或書籍可以支持您的說法呢? 12/21 14:54
回L大大
Control of microcomedone formation throughout a maintenance treatment with
adapalene gel, 0.1%.
Thielitz A, Sidou F, Gollnick H.
J Eur Acad Dermatol Venereol. 2007 Jul;21(6):747-53.
BACKGROUND: Microcomedones representing the clinically non-visible central
precursor lesions of acne are induced by sebaceous hyperplasia as well as
altered follicular growth and differentiation, and evolve into both comedones
and inflammatory lesions. Thus, targeting microcomedone formation is essential
in the prevention and therapeutic control of acne. OBJECTIVE: The aim of this
study was to assess the capacity of adapalene gel, 0.1%, to control the number
of microcomedones after a combination treatment followed by a maintenance
treatment. METHODS: This was a single-site exploratory study in subjects with
a diagnosis of mild to moderate acne vulgaris and the presence of at least
250 microcomedones per cm(2) at screening visit, counted via cyanoacrylate
strips (CyASt). During the first 8 weeks, a combination of adapalene gel (0.1%)
and benzoyl peroxide gel (2.5%) was applied. During the randomized,
investigator-blinded, and vehicle-controlled 12-week maintenance phase,
adapalene once daily (QD), or adapalene alternately with its vehicle once daily
every other day (QoD), or vehicle QD were applied to the face. CyASt sampling
on the forehead was done at baseline, week 8, and week 20. Lesion counting
allowing calculating a defined success rate was done at all visits. RESULTS:
A total of 54 subjects entered the combination phase, and 49 subjects were
randomized into the maintenance phase: 16 in both the adapalene QD and the QoD
group and 17 subjects receiving the vehicle. The microcomedone median count
decreased for all groups until week 8 (end of combination phase) from 319 to
157. Microcomedone counts at the end of the maintenance phase (week 20) showed
a significant percent difference (P = 0.04) between adapalene QoD (-53.5) and
the vehicle (-42.1) and between adapalene QD (-50.6) and the vehicle (P = 0.037)
compared with baseline. CONCLUSION: The application of adapalene gel, 0.1%
monotherapy daily, or alternately every other day, significantly helps to
control the microcomedone count during a 12-week maintenance treatment after
a previous combination therapy with benzoyl peroxide in patients with mild to
moderate acne.
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→ saitoTK:大推風度及引用文獻 12/22 00:53
推 Highwind:不過,49個案,最後一段有用沒用只差8%??,這個有點? 12/22 07:21
→ Highwind:不知道在皮膚科醫師眼中,這些代表的意義是? 12/22 07:22
推 mieya:推風度及引用文獻 12/22 09:27
推 sandyking:大大大推風度及引用文獻 12/22 09:52
推 VAuP:其實p-value在borderline 在臨床應用性不是很高 12/26 23:54