→ ssuchun:唐氏症的病患不會人人都得到白血病 08/03 11:26
推 ltc:那沒輒了啦 題意清楚得很 40歲"幾乎都會"就是Alzheimer囉。 08/03 12:02
這樣應該很難申覆吧...
79 有一個10歲心智發育遲緩男孩，能自行負責日常起居，病人具短頭（Brachycephaly）
、瞼裂較斜，並具明顯內眥贅皮摺，病人並有手掌斷掌紋，胸部理學檢查則顯示具有
Grade III/VI之收縮性雜音。此類病人在40歲時幾乎都會發生下列何種疾病？
A急性白血病 B肝硬化
C慢性腎衰竭 D阿滋海默氏病（Alzheimer's disease）
原答案: D
參考資料
Robbins_Pathologic_Basis_of_Disease_8th
5. Genetic Disorders->Chromosomal Disordes
‧ Children with trisomy 21 have a 10-fold to 20-fold increased risk
of developing acute leukemia. Both acute lymphoblastic leukemias and acute
myeloid leukemias occur. The latter, most commonly, is acute megakaryoblastic
leukemia.[38]
‧ Virtually all patients with trisomy 21 older than age 40 develop
neuropathologic changes characteristic of Alzheimer disease, a degenerative
disorder of the brain.
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