推 chrit:把Mandell抱出來了~~算你狠 03/27 22:37
前文恕刪
根據Mandell, Bennett, & Dolin:
Principles and Practice of Infectious Diseases, 6th ed.
節錄自chapter 29 Glycopeptides (Vancomycin and Teicoplanin), Streptogramins
(Quinupristin-Dalfopristin), and Lipopeptides (Daptomycin)
...A considerable number of studies have found that the bactericidal activity
of vancomycin is concentration independent once a concentration of four or
five times the MIC for the organism is reached, and that the pharmacodynamic
parameters that best express its activity are the time that the vancomycin
concentration is greater than the MIC and the 24-hour area under the
concentration-time curve (AUC)/MIC ratio.
The in vitro postantibiotic effect of vancomycin against staphylococci and
enterococci has been described mostly as of short duration.
Reference: Lowdin E, Odenholt I, Cars O: In vitro studies of pharmacodynamic
properties of vancomycin against Staphylococcus aureus and Staphylococcus
epidermidis. Antimicrob Agents Chemother 1998; 42:2739-2744.
vancomycin的效果是屬於time-dependent killing
雖然它也有一些postantibiotic effect
但效果很短 因此基本上還是屬於time-dependent
典型的concentration-dependent killing Abx例如aminoglycosides即是
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※ 編輯: tobia 來自: 140.112.122.228 (03/27 18:02)