清華大學、交通大學
統 計 學 研 究 所
專 題 演 講
題 目: On the use of statistical methods in comparing Han Chinese
residing in Taiwan and Caucasians for the Major
Histocompatibility Complex Region
主講人: 范盛娟博士 (中央研究院生醫所 副研究員 )
時 間: 95年12月22日（星期五）10：40 - 11：30
（上午10：20-10：40茶會於統計所821室舉行）
地 點: 清大綜合三館837室
Abstract
Genetic dissection of complex diseases is both important and challenging.
The human major histocompatibility complex is involved in many human diseases
and genetic mechanisms thereof. This highly polymorphic chromosome region has
been extensively studied in Caucasians but not as well in Asians. Thus, using
statistical methods in genetic epidemiology, we compared genotypic distribution
s, linkage disequilibria and haplotype blocks between Caucasians and Taiwan’s
Han Chinese population. Moreover, we investigated the population admixture
and phylogenetic history in Han Chinese residing in Taiwan. The results show
that the genotypes of Taiwan's Han Chinese differ significantly from those of
Caucasians but that there is relative homogeneity among the three major Han
ethnic subgroups, Minnan, Hakka and Mainlanders. Differences in allele
frequency (AF) between Taiwanese and Caucasians in some disease-associated
loci may reveal clues to differences in disease prevalence. The heterogeneity
between Han Chinese and Caucasians implies that public databases should be
used with caution in cases where the study population(s) differs from the
population characterized in the database. The high homogeneity we observed
among the Taiwanese subpopulations mitigates the possibility of spurious
association caused by ignoring population stratification in Taiwanese disease
gene association studies. These results are useful for understanding our
genetic background and designing future disease gene mapping studies
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