課程名稱︰應用病理學
課程性質︰系訂必修
課程教師︰饒宇東等人
開課學院：醫學院
開課系所︰護理學系
考試日期（年月日）︰97/6/17
考試時限（分鐘）：120min
是否需發放獎勵金：是
（如未明確表示，則不予發放）
試題 :
一.選擇題:
(A) 1.Reed-Sternberg cell is characteristic of:
(A)Hodgkin lymphoma (B)ALL (C)AML (D)CLL (E)CML
(D) 2.下列何者常見於左心衰竭?
(A)四肢水腫 (B)荳蔻肝 (C)中心靜脈壓上升 (D)肺水腫 (E)以上皆是
(D) 3.下列何者常見於右心衰竭?
(A)肺水腫 (B)心因性氣喘 (C)咳血 (D)中心靜脈壓上升 (E)以上皆是
(E) 4.有關缺血性心臟病的敘述,下列何者正確?
(A)起因於冠狀動脈硬化 (B)心絞痛為症狀之一 (C)可導致心肌梗塞
(D)激烈運動時會加重症狀 (E)以上皆是
(E) 5.下列何者為休克之原因?
(A)心肌梗塞 (B)脊椎受傷 (C)出血 (D)敗血症 (E)以上皆是
(E) 6.有關風濕性心臟病的敘述,何者正確?
(A)為鏈球菌感染之併發症 (B)會引起瓣膜炎 (C)會引起心肌炎
(D)慢性風濕性心臟病會造成瓣膜硬化 (E)以上皆正確
(E) 7.Which of the following statement about Systemic Lupus Erythematosus(SLE)
is correct?
(A)SLE is an autoimmune disease in which the body's own immune system is
directed against the body's own tissues leading to inflammation of
various body tissues.
(B)It can occur at all ages, but is more common in young woman.
(C)Lupus is a complex disease, the cause of which is unknow.
(D)Risk factors include ultraviolet light and some drugs.
(E)All of above.
(D) 8.Cowdry A 包含體與多融合巨細胞(multinucleated giant cells)
是何種感染的病理特徵?
(A)EB病毒感染 (B)A型流行性感冒病毒感染 (C)巨細胞病毒感染 (D)水痘
(A) 9.下列何種疾病與EB病毒的感染無關?
(A)生殖器官的ㄆㄠˋ疹(對不起注音文,那個字打出來會變問號)
(B)鼻咽癌 (C)傳染性單核白血球增多症(Infectious mononucleosis)
(D)post-transplant lymphoproliferative disorder
(C) 10.一個病人拔牙後臉頰出現紅腫熱痛,病理切片下有許多嗜中性白血球的浸潤.
請問最可能是何種病原菌感染?
(A)念珠菌(Candidiasis) (B)粘黴病菌(Mucormycosis)
(C)鏈球菌(Streptococcus) (D)傳染性腦脊髓膜炎(Infectious Meningitis)雙球菌
(D) 11.一個25歲男性,三週前有性接觸,最近在陰莖出現一個紅色無痛的硬性潰瘍,
病理切片最可能找到何種病原菌?
(A)格蘭氏陰性雙球菌 (B)阿米巴痢疾原蟲 (C)分支桿菌 (D)螺旋菌
(B) 12.下列有關結核病的描述何者不正確?
(A)乾酪性壞死是它的病理變化之一
(B)化膿性發炎為結核病的組織學特色
(C)肉芽性發炎是結核病的組織學特徵
(D)結核病的分支桿菌可用Acid-fast染色染出來
(A) 13.偽菌絲(pseudohyphae)是何種病原菌的特徵?
(A)念珠菌 (B)隱球菌 (C)麴菌 (D)分支桿菌
(A) 14.下列何者非惡性腫瘤?
(A)囊腺瘤 (B)淋巴瘤 (C)間皮瘤 (D)黑色素瘤 (E)精細胞瘤
(E) 15.下列何者不是退行性發育的特徵?
(A)多形性 (B)細胞核染色極深 (C)巨大細胞 (D)有絲分裂相多
(E)典型有絲分裂相
(B) 16.下列何者是錯誤的?
(A)癌症是細胞生長不受控制的結果
(B)癌症是一種多株性的細胞增生
(C)非致死性的基因傷害是致癌性的中心思想
(D)致癌形成是多步驟的
(E)癌症是體內的微演化
(C) 17.Burkitt's 淋巴瘤會出現下列何基因的活化?
(A)Ras (B)p53 (C)Myc (D)c-kit (E)Rb
(C) 18.下列何者致癌物和癌症的組合是錯誤的?
(A)黃麴毒素--肝癌 (B)亞硝酸鹽--胃癌
(C)芳香胺,偶氮染--大腸癌 (D)Benzo-α-pyrene--肺癌
(A) 19.下列何種病毒可能帶有致癌基因?
(A)急性RNA轉形病毒 (B)慢性RNA轉形病毒
(C)急性DNA轉形病毒 (D)慢性DNA轉形病毒
(C) 20.以下哪些疾病,病人可能伴有心臟畸形的問題?(1)Edwards syndrome, (2)
Huntington's disease, (3)Turner syndrome, (4)trisomy 13
(A)(1),(2),(4) (B)(2),(3),(4) (C)(1),(3),(4) (D)(2),(4) (E)(3),(4)
(B) 21.有位4歲女孩被父母帶到小兒科求診,醫師懷疑這位女孩可能是唐氏症(Down
syndrome),請問下列何種針對第21對染色體的分子診斷方法可確定這位小朋友
罹患唐氏症?
(A)RT-PCR (B)FISH (C)DNA polymorphism (D)Southern blot analysis
(A) 22.下列哪一種發生於幼兒的腫瘤,其治療方式以化學治療為主?
(A)neuroblastoma (B)cavernous hemangioma (C)capillary hemangioma
(D)mature teratoma (E)lymphangioma
(D) 23.下列何種遺傳疾病的遺傳模式為性聯遺傳?
(A)cleft lip (B)Huntington's disease (C)Edwards syndrome(trisomy 18)
(D)Hemophilia A (E)Marfan's syndrome
(B) 24.Fragile-X syndrome 是triple-repeat expansion disease之一種,有關
fragile-X syndrome的事實,以下何者為非?
(A)病人X染色體有不正常之 CGG triple repeats 增長
(B)遺傳模式是 autosomal dominant
(C)X 染色體中的 CGG triple repeats 的數目愈多,病人發病年齡愈早,症狀也愈
嚴重
(D)病人除了有臉部外觀的異常,也常伴有智商低下
(E) 25.有關唐氏症,何者為非?
(A)發生率約為1/700 (B)約40%的唐氏症病人伴有心臟病
(C)智能不足,斷掌為臨床常見表現 (D)是染色體第二十一對出問題
(E)好發於女嬰
(D) 26.下列何者會造成腳部的黑色壞疽?
(A)急性汞中毒 (B)急性鉛中毒 (C)慢性銅中毒 (D)慢性砷中毒
(C) 27.下列何者需要外科手術縫合?
(A)擦傷 (B)淤血傷 (C)裂傷 (D)燙傷
(B) 28.鼻咽癌病人接受鈷60放射線治療後引起口乾症是一種:
(A)免疫性疾病 (B)輻射線性傷害 (C)癌症的擴散 (D)EBV病毒感染
(D) 29.下列何者為急性巴拉刈中毒的首要傷害器官?
(A)大腦 (B)小腦 (C)肝臟 (D)腎臟
(C) 30.酒精會引起:
(A)肺栓塞 (B)腎盂炎 (C)小結節性肝硬化 (D)腎結石
(B) 31.服用安非他命會造成:
(A)乾眼症 (B)高體溫症 (C)藥物過敏性無防禦型休克 (D)全身性溶血症
(D) 32.急性炎症(acute inflammation)最早出現的變化是:
(A)吞噬作用(phagocytosis) (B)血管通透性增加
(C)血管外滲(extravasation) (D)血管擴張
(B) 33.在血管外滲(extravasation)的過程中,下述現象的順序依序為何?(1)黏著
(adhesion), (2)靠邊(margination), (3)滾動(rolling), (4)移出
(transmigration), (5)活化(integrin)
(A)12345 (B)23514 (C)35214 (D)51324
(D) 34.下列急性發炎的主要現象中,何者不能單純以血管反應來解釋?
(A)紅 (B)腫 (C)熱 (D)痛
(C) 35.典型的結核病(tuberculosis, TB)病灶,在組織型態學上的主要表現為何?
(A)漿液性(serous)發炎 (B)化膿性(purulent)發炎
(C)肉芽腫性發炎(granulomatous) (D)纖維化(fibrosis)
(A) 36.關於慢性炎症(chronic inflammation),何者較不正確?
(A)皆由久未消退的急性炎症衍生而來 (B)以單核發炎細胞為主要浸潤細胞
(C)大多伴隨組織的破壞 (D)多半隨再生與修復
(C) 37.傷口的一期癒合(healing by first intention)與二期癒合(healing by second
intention),兩者最主要的差別在於:
(A)癒合速度 (B)傷口出血量 (C)傷口收縮 (D)疤痕大小
(C) 38.微小病變(minimal change disease)是下列何種細胞之foot process不正常?
(A)Mesangial cells (B)Endothelial cells
(C)Podocytes (D)Parietal epithelial cells
(A) 39.Which one is most important for nephrotic syndrome(腎病症候群)?
(A)Heavy proteinuria(>3.5 gm/day) and hypoalbuminemia(<3 gm/dl).
(B)Hyperlipidemia(cholesterolnemia, triglyceridemia) and hypertension.
(C)Edema and oligouria.
(D)Hypertension and hematuria.
(A) 40.有關子宮頸癌,下列何者正確?
(A)並非所有上皮內贅瘤(Cervical Intraepithelial Neoplasia, CIN)都會演變成
子宮頸癌.
(B)一般而言,只有分化差的鱗狀細胞癌(Poorly-differentiated squamous cell
carcinoma)與人類乳頭瘤病毒(HPV)感染有關.
(C)大部分子宮頸腺癌(Adenocarcinoma)與人類乳頭瘤病毒(HPV)感染無關.
(D)與子宮頸癌發生最相關的人類乳頭瘤病毒是第11型(HPV type 11).
(D) 41.有關子宮內膜增生(Endometrial hyperplasia),下列何者正確?
(A)與長期黃體激素(progesterone)刺激有關
(B)目前廣用的子宮內膜增生的分類中,單純性增生(simple hyperplasia)與子宮
內膜癌的發生最相關
(C)無排卵性月經週期(Anovulatory cycle)不會造成子宮內膜增生
(D)卵巢的濾泡顆粒性細胞瘤(Granulosa Cell Tumor)常伴隨有子宮內膜增生現象
(B) 42.停經前婦女最常見的子宮腫瘤是:
(A)惡性平滑肌肉瘤(Leiomyosarcoma) (B)平滑肌瘤(Leiomyoma)
(C)子宮內膜息肉(Endometrial polyp) (D)肌層腺體症(Adenomyosis)
(C) 43.有關卵巢腫瘤下列何者正確?
(A)最常見的卵巢腫瘤為生殖細胞瘤(Germ cell tumor)
(B)卵巢惡性腫瘤中以黏液性囊腺癌(Mucinous cystadenocarcinoma)最常見
(C)成熟性畸胎瘤(Mature teratoma)是生殖細胞瘤(Germ cell tumor)中最常見
(D)濾泡顆粒性細胞瘤(Granulosa cell tumor)較常發生在青春期女性
(A) 44.引起腹膜腔假黏液瘤(Pseudomyxoma peritonei)最常見的原因是原發於下列何處
的黏液性腫瘤(Mucinous tumor)?
(A)闌尾(Appendix) (B)卵巢(Ovary) (C)胰臟(Pancreas) (D)子宮頸(Cervix)
(D) 45.有關女性乳房疾病下列何者正確?
(A)最常見的惡性腫瘤是Paget氏症(Paget's disease)
(B)與乳癌的預後最相關的因素是腫瘤的大小(Tumor size)
(C)纖維囊腫性病變(Fibrocystic disease)不會與乳癌的發生有關
(D)纖維腺瘤(Fibroadenoma)是女性乳房最常見的良性腫瘤
(C) 46.高血壓性腦出血最常發生於何處?
(A)額葉 (B)視丘 (C)基底核 (D)枕葉 (E)頂葉
(C) 47.好發於小孩小腦部位的神經腫瘤是:
(A)視神經瘤 (B)神經鞘瘤 (C)髓芽細胞瘤 (D)膠原細胞瘤 (E)血管瘤
(D) 48.巴金森氏(Parkinson's disease)症的病灶最常發生於腦的何處?
(A)視丘 (B)基底核 (C)海馬迴 (D)黑質 (E)嗅葉
(C) 49.下列哪一種腦部病變在病理上不容易見到有病灶?
(A)腦挫傷(contussion) (B)硬腦膜外出血(epidural hemorrhage)
(C)腦震盪(concussion) (D)腦腫瘤(Brain tumor) (E)以上皆非
(B) 50.下列哪一個是用來描述因腦部損傷所造成的胃潰瘍?
(A)Curling氏潰瘍 (B)Cushing氏潰瘍 (C)幽門螺旋桿菌潰瘍
(D)消化性潰瘍 (E)NSAID潰瘍
(D) 51.下列的顱內出血多屬於自發性(spontaneous)出血,除了:
(A)動脈瘤(aneurysm) (B)動靜脈畸形 (C)血管瘤(hemangioma)
(D)腦挫傷 (E)腦瘤
(D) 52.關於退化性關節炎(Osteoarthritis),何者為非?
(A)較常見於老人 (B)Heberden's node(結節)屬之
(C)較常見於大關節 (D)只有原發性
(E) 53.下列何項非癌症侵犯所引起的症狀?
(A)霍納氏症候群(Horner's syndrome)
(B)潘科斯特氏症候群(Pancoast's syndrome)
(C)上腔靜脈症候群(Superior vena cava syndrome)
(D)聲音嘶啞
(E)百日咳(Whooping cough)
(A) 54.Which matching pair is correct?
(A)Unconjugated hyperbilirubinemia-kernicterus
(B)Hemolysis-conjugated hyperbilirubinemia
(C)Biliary atresia-Unconjugated hyperbilirubinemia
(D)Neonatal(giant cell) hepatitis-liver cirrhosis
(C) 55.Which matching pair is most appropriate?
(A)Acute hepatitis A-development of chronic hepatitis A
(B)Acute hepatitis E-development of liver cirrhosis
(C)Acute hepatitis C-development of chronic hepatitis C
(D)Acute hepatitis B in adult-development of chronic hepatitis B
(D) 56.Which matching pair is NOT appropriate?
(A)Fulminant hepatitis A-massive liver necrosis
(B)Chronic hepatitis B-hepatocellular carcinoma
(C)Chronic hepatitis C-hepatocellular carcinoma
(D)Fulminant hepatitis B-steatohepatitis
(D) 57.Which one is NOT a characteristic feature of liver cirrhosis?
(A)Diffuse bridging fibrous septum formation (B)Varices
(C)Parenchymal nodules (D)Bile duct damage
(D) 58.Which matching pair is NOT appropriate?
(A)Alcoholic hepatitis-Mallory bodies
(B)Alcoholic cirrhosis-liver weight >3000 gm
(C)Nonalcoholic steatohepatitis(NASH)-obesity with fatty liver
(D)Primary biliary cirrhosis-chronic bile duct stone and infection
(B) 59.Which matching pair is NOT appropriate?
(A)Liver rejection-bile duct damage
(B)Reye syndrome-massive liver necrosis
(C)Hepatocellular adenoma-oral contraceptives
(D)Hepatocellular carcinoma-cirrhosis and chronic hepatitis B
(C) 60.Which matching pair is NOT appropriate?
(A)Pancreatic head cancer-obstructive jaundice
(B)Acute pancreatitis-fat necrosis
(C)Hepatitis B vaccination-decrease in HBsAg(+) rate in adults
(D)Hepatitis B vaccination-decrease in hepatocellular carcinoma in
children
(D) 61.下列敘述何者為非?
(A)leukoplakia 是一種 premalignant lesion
(B)Herpes simplex 在口腔的感染,起病理病變可以 Tzanck test 來檢測
(C)Aphthous ulcer 是一種潰瘍,不藥物治療亦能自動復原
(D)Pleomorphic adenoma 是唾液腺少見的惡性腫瘤
(B) 62.現今認為胃潰瘍和胃炎大部分是來自於微生物感染,請問其感染致病微生物是?
(A)Staphylococcus (B)Helicobacter pylori
(C)Pneumococcus (D)Candida albicans
(D) 63.胃腫瘤的種類甚多,請問其腫瘤細胞源自於中胚層者是:
(A)adenocarcinoma (B)squamous cell carcinoma
(C)lymphoma (D)gastrointestinal stromal tumor
(C) 64.當一位大學生因面臨期末考,在上唇內部產生了單一淺而小且疼痛的潰瘍,她最可
能得了下列哪一種疾病?
(A)Herpes simplex infection (B)leukoplakia
(C)Aphthous ulcer (D)squamous cell carcinoma
(A) 65.巨結腸症(Hirschsprung's disease)是起因於:
(A)肌肉層和黏膜下層缺少神經細胞和神經節 (B)E. coli感染
(C)飲食過度 (D)不良大便習慣
(B) 66.痔瘡(Hemorrhoid)的病理變化是:
(A)大腸肥大性息肉 (B)肛門之靜脈叢擴張充血
(C)黴菌感染增生 (D)大腸淋巴系統阻塞
(E) 67.下列哪一種甲狀腺腫瘤不是源自於濾泡細胞(follicular cell)?
(A)乳頭狀癌 papillary carcinoma (B)濾泡癌 follicular carcinoma
(C)濾泡腺瘤 follicular adenoma (D)未分化癌 anaplastic carcinoma
(E)髓質癌 medullary carcinoma
(E) 68.生長激素腺瘤(growth hormone adenoma)不會引起下列何種症狀?
(A)末端肥大 acromegaly (B)巨人症 gigantism (C)頭痛
(D)視野缺陷 (E)多毛症 hirsutism
(A) 69.脛骨前黏液水腫(pretibial myxedema)是哪一疾病的特徵?
(A)葛雷夫氏病 (Graves disease) (B)多結節性甲狀腺腫 (multinodular goiter)
(C)橋本氏甲狀腺炎 (Hashimoto thyroiditis) (D)呆小症 (cretinism)
(E)亞急性甲狀腺炎
(C) 70.最常引起原發性副甲狀腺機能抗近的原因是:
(A)原發性副甲狀腺增生 (B)副甲狀腺癌 (C)副甲狀腺腺瘤
(D)腎衰竭 (E)骨質疏鬆
(D) 71.下列哪一種原因不會引起庫辛氏症候群(Cushing's syndrome)?
(A)腎上腺皮質腺瘤 (B)原發性腎上腺皮質增生 (C)長期服用類固醇藥物
(D)Conn's syndrome (E)Cushing's disease
(B) 72.(pheochromocytoma)(multiple endocrine neoplasia)?
(A)type I (B)type II (C)type III (D)type IV (E)type V
二.配合題:
(B)73.Type I Hypersensitivity (A)Immune Complex-mediated
(C)74.Type II Hypersensitivity (B)Eosinophils and Mast cells-mediated
(A)75.Type III Hypersensitivity (C)Fc/Complement-mediated
(D)76.Type IV Hypersensitivity (D)Cell-mediated
Match the marker with the disease:
(D)77.CD3 (A)AML
(B)78.CD20 (B)B-cell Lymphoma
(C)79.TdT (C)ALL
(A)80.MPO (D)T-cell Lymphoma
(C)81.鼻竇炎(Sinusitis) (A)枯草熱(Hay fever)
(E)82.鼻咽癌(Nasopharyngeal carcinoma) (B)乾酪性壞死(Caseous necrosis)
(D)83.氣喘(Asthma) (C)骨髓炎(Osteomyelitis)
(A)84.過敏性鼻炎(Allergic rhinitis) (D)陣發性支氣管痙攣
(B)85.結核病 (E)頸部淋巴結腫大
(B)86.骨軟骨瘤(Osteochondroma) (A)纖維性發育不良(Fibrous dysplasia)
(C)87.類風濕性關節炎(Rheumatoid arthritis) (B)可能惡性變化成軟骨肉瘤
(Chondrosarcoma)
(A)88.Albright 氏症(Albright's triad) (C)關節翳(Pannus)形成
(D)89.骨發生不全(Osteogenesis imperfecta) (D)Type I collagen 缺陷
(E)90.骨質疏鬆(Osteoporosis) (E)Estrogen
(D)91.Seminoma (A)clear cells in majority
(C)92.Chinese herb nephropathy (B)old age and high prevalence rate
(AB)93.Condyloma acuminatum (C)interstitial fibrosis
(A)94.Renal cell carcinoma (D)with lymphocytes and radiosensitive
(B)95.Prostate cancer (E)central zone
(A+B)human papilloma virus
(A+C)with lymphocytes and radioresistant
三.是非題: Yes:A ; No:B
(B)96.The main cause of cellular coagulation necrosis is due to short of
nutrition.
(A)97.During hepatic ischemic change, we may observe some enzyme levels such
as GOT, elevated in serum.
(B)98.Over physical exercise may induce muscular hyperplasia.
(B)99.Apoptosis may be induced by tuberculosis.
(A)100.In the tissue hemorrhage, hemosiderin pigment can always be seen in the
damage region.
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