課程名稱︰分析化學丁
課程性質︰必修
課程教師︰何國榮
開課系所︰醫技系、藥學系
考試時間︰2006/4/24 10:20~12:10
試題 :
Analytical Chemistry (120 points)
1. Briefly answer the following questions. 30%
(a) sampling
(b) sample preparation
(c) qualitative analysis
(d) amphiprotic species
(e) variance
(f) false negative
(g) limit of quatitation
(h) quality assessment
(i) buffer solution
(j) isoelectric focusing
2. Draw the following three titration curves on the same diagram. 12%
(a) titration of a strong acid with a strong base
(b) titration of a weak acid which has the same concentration as the
strong acid in (a)
(c) titration the same strong acid as in (a) but is more diluted
3. Derive the exact equation for a buffer solution. 5%
4. In a weak acid solution, please show that the dissociation is less
than 5% if Ka/C ﹤2.5*10^-3.
5. Explain the fact that the elimination of the contribution of H2O
dose not significantly simplify the calculation of pH of an amphiprotic
solution. 5%
6. Calculate the [H+] of a 10^-8 M KOH solution. 5%
7. (a) State a method and the steps for the detection of systematic error.
(b) State the reason that one can not make a conclusion that there is
no systematic error. 8%
8. A 25 mL class A pipet delivers 25.00 ±0.03mL, calculate the uncertainty
if you use (a) the same pipet (b) different pipet to deliver 100 mL
solution. 6%
9. List the two assumptions in the concentration of a calibration curve. 6%
10. If accuracy is defined as how close an average value to the true value.
State the reason that accuracy can be improved by increasing the number
of measurement on the same sample. 5%
11. You prerared a 0.250 M NH3 solution by diluting 8.45(±0.04) mL of
28.0(±0.5) wt%NH3 [density = 0.899(±0.003) g/mL] up to 500.0 (±0.2) mL.
Find the uncertainty in 0.250 M. Consider the molecular mass of NH3,
17.031 g/mol, to have negligiable uncertainty. 5%
12. Convert [H+] = 1.0*10^-5 to a pH value. 4%
13. State the reason that, in general, five points are needed to establishing
a calibration curve. 5%
14. State the reason of estimating detection limit before establishing a
detection limit. 5%
15. State the advantages of using internal standard in the establishing a
calibration curve. 5%
16. State (a) purpose (b) requirements in the validation of an analytical
method in pharmaceutical chemistry. 3+5%
註：超過98分以98分計。
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