※ 引述《reye (第14個大滿貫)》之銘言：
: ※ 引述《Juipeter (我要當貓頭鷹^_^)》之銘言：
: : P.5 最後一行 造成溶血，包括紅血球，血小板...
: : P.7 (2)第四行 可以block住presynaptic的...
: 可是(2)和(3)那時候聽老師的意思是(2)是block突觸後的receptor
: (3)是不讓突觸前的'抑制型'neurotransmitter釋放...我是覺得應
: 該是在不同地方會造成不同效果啦...
我還是覺得老師講錯了，不過因有爭議，將該訂正改為討論問題
討論一:P.345未提到其有和postsynaptic receptor binding
討論二:以下為網路上對於此toxin action的闡明:
Tetanospasmin initially binds to peripheral nerve terminals. It is transported
within the axon and across synaptic junctions until it reaches the central
nervous system. There it becomes rapidly fixed to gangliosides at the presynap-
tic inhibitory motor nerve endings, and is taken up into the axon by endocytos-
is. The effect of the toxin is to block the release of inhibitory neurotransmi-
tters (glycine and gamma-amino butyric acid) across the synaptic cleft, which
is required to check the nervous impulse.
The receptor to which tetanospasmin binds has been reported as ganglioside
GT and/or GD1b, but its exact identity is still in question.
ref:http://www.bact.wisc.edu/Bact330/lecturetetbot
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