※ 引述《catwings (藍貓)》之銘言：
: 這是我第一次在這邊po文，假如有不合的請告訴我>"<
: 我想請問一下有關於動物醫療過失方面的知識，
: 我爬過文，也找過精華區，上網查有關動物法各種知識，
: 所查到的資料少的可憐，最後只有ｐｏ文請大家幫忙一途，
: 事情是這樣的，我親戚家養了一隻古代牧羊犬，取名叫圓圓，是很可愛的女生
: 過年前因為他有輕微的皮膚病而帶她去看醫生，醫生當時幫她打治療介癬蟲的藥，
: 回家後就陷入昏迷，原本的獸醫院因為過年而休診，所以轉往台北的獸醫院急診，
: 台北那邊的醫生說，牧羊犬類對於某種藥物會有過敏導致昏迷的情況，
: 當時的打的藥很有可能就是會造成他過敏的藥，而且劑量也有過重，
: 有可能是打針的獸醫一時疏忽，因為沒有解法只能等看看他會不會自己清醒，
: 就在昨天我打電話過去關心圓圓的時候，才知道熬了兩個星期她已經走了，
: 原本幫她打針的獸醫不覺得是他的錯，可是圓圓本來是隻健康的狗，年齡也才一歲半
: 突然間就昏迷然後就不明不白的走了，這不太可能吧．．．
恕刪...
英國古代牧羊犬（Old English Sheepdog）是牧羊犬(collie)的一種
http://www.msnbc.msn.com/id/5518665
牧羊犬之所以不能使用疥癬的藥物ivermectin主要是其有基因上的變異（MDR-1）
It is well known that Collies and related breeds can have adverse reactions
to drugs such as ivermectin, loperamide (ImodiumR), and others. It was
previously unknown why some individual dogs were sensitive and others were not.
Advances in molecular biology at the Veterinary Clinical Pharmacology
Laboratory at Washington State University's College of Veterinary Medicine have
led to the discovery of the cause of multi-drug sensitivity in affected dogs.
The problem is due to a mutation in the multi-drug resistance gene (MDR1).
This gene encodes a protein, P-glycoprotein, that is responsible for pumping
many drugs and other toxins out of the brain. Dogs with the mutant gene can not
pump some drugs out of the brain as a normal dog would, which may result in
abnormal neurologic signs. The result may be an illness requiring an extended
hospital stay--or even death.
Approximately 3 of every 4 Collies in the United States have the mutant MDR1
gene. The frequency is about the same in France and Australia, so it is likely
that most Collies worldwide have the mutation. The MDR1 mutation has also been
found in Shetland Sheepdogs (Shelties). Australian Shepherds, Old English
Sheepdogs, German Shepherds, Long-haired Whippets, Silken Windhounds, and a
variety of mixed breed dogs.
原文摘自
http://www.vetmed.wsu.edu/depts-VCPL/
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