推 timothy70417:推! 08/05 08:12
※ 引述《rexking (rex)》之銘言：
: 醫學一66
: 第66題A選項:
: 皮細胞會分泌TGF-B、PGE2等”抗發炎”物質來調控共生菌引起的免疫反應。
: PGE2作用在不同受器，會產生抗發炎及導致發炎兩種不同結果，作用在受器EP1~3會加強
: 發炎反應，作用在受器EP4則會抑制發炎。因此認為第66題A選項上皮細胞會分泌TGF-B
: 、PGE2等”抗發炎”物質來調控共生菌引起的免疫反應。有爭議。
: 因為PGE2的作用取決於作用的受器，無法直接將其分類為發炎物質或抗發炎物質，而且在
: 大部分生理藥理學的用書裡，多強調其為發炎的生理及藥理效用，而且許多藥物機轉
: (如NSAID)也都建立在抑制PGE2，能夠抗發炎。因此認為此題選項A有爭議，此題四個選項
: 皆有錯誤，建議送分。
: 以下附上參考資料來源
: http://jpet.aspetjournals.org/content/319/3/1096.abstract
: 希望有任何意見都可以一起提出來討論~
: 感謝~
如果加上這個不知道好不好?
根據Kuby Immunology 第五版Chapter 15 (P349)內文提到:
Metabolism of arachidonic acid by the cyclooxygenase pathway produces
prostaglandins and thromboxanes. Different prostaglandins are produced by
different cells: monocytes
and macrophages produce large quantities of PGE2 and PGF2; neutrophils
produce moderate amounts of PGE2; mast cells produce PGD2. Prostaglandins
have diverse physiological effects, including increased vascular
permeability, increased vascular dilation, and induction of neutrophil
chemotaxis. The thromboxanes cause platelet aggregation and constriction of
blood vessels.
依照此文字敘述, 又加上Robbins對發炎的定義:
Acute Inflammation
Acute inflammation is a rapid response to an injurious agent that serves to
deliver mediators of host defense-leukocytes and plasma proteins-to the site
of injury. Acute inflammation has three major components: (1) alterations in
vascular caliber that lead to an increase in blood flow; (2) structural
changes in the microvasculature that permit plasma proteins and leukocytes to
leave the circulation; and (3) emigration of the leukocytes from the
microcirculation, their accumulation in the focus of injury, and their
activation to eliminate the offending agent (Fig. 2-2).
故推論PGE2不是一種抗發炎物質, 因此本題A選項應為錯誤
建議此題送分
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