→ Escaper:化療應該都是一藥一bag吧 08/14 00:43
推 sharkimage:查注射劑調配的那一大本書 說不定有資料 08/14 00:50
推 holdon:injection那本可以查一下 08/14 01:11
→ wylscott:謝謝回答 ^^" 08/14 12:12
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作者: liban (錄取率創新高 改行賣雞排) 看板: pharmacist
標題: Re: [問題] 5-Fu和Cisplatin會打在同一個bag裡嗎？
時間: Sun Aug 14 02:00:58 2011
以下來自micromedex
Cisplatin-Fluorouracil
Y-Site Compatible
Admixture Incompatible
Syringe Compatible
Admixture Detail：
Cisplatin 0.2 mg/mL
Fluorouracil 1 mg/mL
Incompatible
In Normal saline- Sodium chloride 0.9%
Physical Compatibility: Physically compatible. No haze
or particulate formation, color change, or gas evolution.
Chemical Stability: Chemically unstable. About 10% cisplatin loss occurred in
90 minutes and about 25 to 30% loss occurred in 3 to 4 hours. No fluorouracil
loss occurred within the study period.
Storage: Room temperature of 24 to 26 °C exposed to fluorescent light and
protected from light.
Study Period: Up to 24 hours.
Method: Visual observation and stability-indicating HPLC analysis of drug
concentrations.
Container: Polyvinyl chloride (PVC) bags.
Ref:Stewart CF, Fleming RA: Compatibility of cisplatin and fluorouracil
in 0.9% sodium chloride injection Am J Hosp Pharm: 1990 47: 1373-7
------------------------------------------------------------------------------
Cisplatin 0.5 mg/mL
Fluorouracil 10 mg/mL
Incompatible
In Normal saline- Sodium chloride 0.9%
Physical Compatibility: Physically compatible. No haze
or particulate formation, color change, or gas evolution.
Chemical Stability: Chemically unstable. About 10% cisplatin loss occurred in
90 minutes and about 25 to 30% loss occurred in 3 to 4 hours. No fluorouracil
loss occurred within the study period.
Storage: Room temperature of 24 to 26 °C exposed to fluorescent light and
protected from light.
Study Period: Up to 24 hours.
Method: Visual observation
Container: Polyvinyl chloride (PVC) bags.
Ref:Stewart CF, Fleming RA: Compatibility of cisplatin and fluorouracil
in 0.9% sodium chloride injection Am J Hosp Pharm: 1990 47: 1373-7
-----------------------------------------------------------------------------
Cisplatin 0.5 mg/mL
Fluorouracil 10 mg/mL
Incompatible
In Normal saline- Sodium chloride 0.9%
Physical Compatibility: Not reported.
Chemical Stability: Chemically unstable. About 80% loss of cisplatin occurred
in 24 hours.
Storage: Room temperature protected from light.
Study Period: 15 days.
Method: HPLC analysis of drug concentrations.
Container: Polyvinyl chloride (PVC) plastic bags.
Ref:Lokich J, Anderson N, Bern M, et al: Combined floxuridine and cisplatin
in a fourteen day infusion Cancer: 1988 62: 2309-12
※ 引述《wylscott (林 佳樹)》之銘言：
: 最近有遇到這個例子
: 雖然我和幾位藥師覺得怪怪的
: 因為Cisplatin是酸性
: 而5-Fu是鹼性
: 但是查了Micromedex
: 並沒有Drug-Drug interaction
: 不過醫師堅持這樣用我也沒辦法
: 請問有其他在醫院的同仁們有聽過這種用法嗎？
: 這樣藥效會不會減弱呢？
: 會的話
: 請問你們認為影響的機轉是什麼？
: 麻煩解惑一下謝謝～
--
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推 wylscott:謝啦～好久不見啊 ^^" 08/14 11:53
→ liban:樓上又高又帥...好久不見阿^^ 08/17 21:26
推 goat1:讚！ 08/21 10:57