【研究方向】慢性發炎相關腫瘤，腫瘤微環境，免疫過度活化與癌症發生
https://goo.gl/kT2K7mhttps://goo.gl/kT2K7m
【徵才單位】北醫轉譯醫學學程 張書君助理教授/台北醫學大學乳房外科 洪進昇醫師
【工作地址】北醫乳房外科 & 國防醫學院 (內湖區)
【工作內容】1. 細胞實驗、基本分生實驗 (PCR、WB、FACS)；
2. 其他交辦事項
【徵才條件】1. 生物相關科系畢業之學士或碩士級研究助理
2. 有細胞培養經驗者佳
【薪資待遇】比照科技部 (學士級第一年31,520元；碩士級第一年36,050元)
【聯絡方式】有意願者請備履歷寄至信箱 sc.chang@tmu.edu.tw
【現階段計畫】
Shu-Chun Chang and Chin-Sheng Hung. The role of SAG-UPS/F-Boxes in breast
cancer microenvironment and metastasis. 106年度臺北醫學大學-附設醫院專題研
究計畫. 106TMU-TMUH-15, Jun/2017~May/2018.
Shu-Chun Chang and Chin-Sheng Hung. Ubiquitin regulatory mechanisms via
extracellular CXCR4 and intracellular SAG-UPS in breast cancer metastasis.
105年度臺北醫學大學-附設醫院專題研究計畫. 105TMU-TMUH-06, Jun/2016~May/2018.
Shu-Chun Chang. Investigating a key switch between immune-overactivation and
tumorigenesis. MOST 105-2320-B-038-007-MY2, Ministry of Science and Technology,
Feb/2016~Jul/2017.
Shu-Chun Chang. Investigating a key switch between immune-overactivation and
tumorigenesis. TMU104-AE1-B10, Taipei Medical University, Nov/2015~Oct/2017.
【近三年發表】
Wai Hoe Lau, Xiphias Ge Zhu, Shamaine Wei Ting Ho, Shu Chun Chang,Jeak
Ling Ding. Combinatorial treatment with polyI:C and anti-IL6 enhances
apoptosis and suppresses metastasis of lung cancer cells. Oncotarget (IF:
5.008), 2017 Mar:1–21.
Shu-Chun Chang* and Wei-Chung Vivian Yang*. Hyperglycemia, Tumorigenesis, and
Chronic Inflammation. Critical Reviews in Oncology/Hematology (IF: 5.039),
2016; 108(2016):146–153. *These authors contributed equally to this work.
Shu-Chun Chang and Jeak Ling Ding. SAG-UPS regulates malignant transformation
- from chronic inflammation to pro-tumorigenesis to liver cancer. Cell Death
& Disease (IF: 5.014), 2015 (6) e1941; doi:10.1038/cddis.2015.312.
Shu-Chun Chang, Winnie Qing Wei Choo, Han Chong Toh and Jeak Ling Ding.
SAG-UPS attenuates proapoptotic SARM and Noxa to confer survival advantage to
early hepatocellular carcinoma. Cell Death & Discovery (IF: N/A), 2015;
doi:10.1038/cddiscovery.2015.32.
Shu-Chun Chang and Jeak-Ling Ding. Ubiquitination by SAG regulates macrophage
survival/death and immune response during infection. Cell Death &
Differentiation (5-Year IF: 8.371), 2014 Sep; 21:1388–98.
Anthony Magee, Antonio Konitsiotis, Biljana Jovanovic, Shu-Chun Chang,
Paulina Ciepla, Naoko Masumoto and Ed Tate. Lipidation of Hedgehog proteins:
function, enzymology and therapeutic potential in pancreatic cancer.
Pancreatology (5-Year IF: 2.275), 2014 Mar-Apr; 14(2):e4.
Antonio D Konitsiotis*, Shu-Chun Chang*, Biljana Jovanovic, Paulina Ciepla,
Naoko Masumoto, Christopher P Palmer, Edward W Tate; John R Couchman and
Anthony I. Magee. Attenuation of Hedgehog acyltransferase-catalyzed Sonic
hedgehog palmitoylation causes reduced signaling, proliferation and
invasiveness of human carcinoma cells. PLOS ONE (5-Year IF: 3.73), 2014 Mar;
9(3):e89899. *These authors contributed equally to this work.
【其他備註】通過面試後即刻聘用，
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