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Any candidate with a PhD is encouraged to apply, if you love:
Technology development, including Fluorescent Tools for reading &
manipulating cell signaling
Biological adventures, including Physical & Chemical Biology, Cell &
Molecular Biology, Developmental Biology
Drug discovery, including small molecules that inhibit dysregulated
signaling in disease e.g. cancer.
We believe in what Richard Feynman said “If you’re not having fun, you are
not learning. There’s a pleasure in finding things out.”
1) Having fun is an essential part of our research life.
Our students and postdoc trainees and the PI always find unexpected fun in
their biological adventures because we are an interdisciplinary lab, focusing
on visualizing inner life of living cells and animals.
The cells’ inner life is like a glowing beautiful world of Avatar, after we
label many proteins in the cell with multicolor fluorescent reporters.
2) Our research interests span the fields of Physical Biology, Chemical
Biology, Structural Biology, Protein Engineering, Cell & Molecular Biology,
Developmental Biology, and Drug Discovery.
We apply Physics, Chemistry and Engineering to design biological tools for
visualizing and manipulating dynamic cell signaling in vivo in order to
understand animal development and homeostasis, because dynamical features of
signaling are the essence of living organisms.
Effector proteins such as proteases and kinases regulate almost every major
signaling pathways, and protein-protein interactions (PPIs) define
specificity of signal transduction from extracellular cues to the appropriate
intracellular effector proteins.
3) We have developed new classes of fluorescent reporters of proteases,
kinases, small GTPases, and PPIs.
These reporters achieve large dynamic range, high brightness and fast
kinetics, in addition being genetically encoded requiring no exogenous
cofactor for non-invasive imaging.
Our reporters enable robust and rapid imaging of dynamic signaling in living
cells and animals with unexpected fun, identifying small molecules that
inhibit dysregulated signaling in disease such as cancer.
4) Other biological tools we are developing include:
Chemogenetic tools for manipulating protein interaction and liquid-liquid
phase separation.
A genetically encoded photosensitizer for activating caspase and apoptosis
signaling and ablating single cells in live animals; singlet oxygen-mediated
proximity labeling technologies for identifying weak and transient PPIs by
mass spectrometry.
5) We apply the novel technologies to understand exciting biology.
We have shared these tools by depositing them to not-for-profit
organizations, e.g. Addgene, Bloomington Stock Center.
Together let’s explore fascinating biology and discover life-saving
therapeutics while having fun in the biological adventures!
Contact: Xiaokun Shu, Professor at Department of Pharmaceutical Chemistry &
CVRI, University of California at San Francisco.
Website: https://shulab.ucsf.edu
UCSF profile: https://profiles.ucsf.edu/xiaokun.shu
Please email your CV and 3 reference letters to [email protected]
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